ATP5MJ
ATP synthase F(0) complex subunit j, mitochondrial
Also known as: 6.8PL, ATP5MPL, ATP68_HUMAN, C14orf2, MLQ, MP68
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P56378
- Gene
- ATP5MJ
- Ensembl
- ENSG00000156411
- Chromosome
- 14
- Canonical length
- 58 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nucleoli fibrillar center,Mitochondria
- Quaternary structure
- Homooctamer
OverviewNCBI Gene
Predicted to be involved in proton motive force-driven ATP synthesis. Located in fibrillar center and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
58 residues, UniProt reviewed canonical sequence.
>P56378|ATP5MJ
1 MLQSIIKNIW IPMKPYYTKV YQEIWIGMGL MGFIVYKIRA ADKRSKALKA SAPAPGHHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ATP5MJ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 543 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 543 nTPM
- skeletal muscle: 459 nTPM
- tongue: 440 nTPM
- cerebral cortex: 375 nTPM
- amygdala: 374 nTPM
- basal ganglia: 355 nTPM
Single-cell type
- parietal cells: 2,367 nCPM
- hofbauer cells: 1,212 nCPM
- esophageal suprabasal cells: 1,178 nCPM
- hepatocytes: 1,085 nCPM
- esophageal apical cells: 1,057 nCPM
- gastric progenitor cells: 1,010 nCPM
Immune cell
- total PBMC: 657 nTPM
- neutrophil: 520 nTPM
- classical monocyte: 514 nTPM
- intermediate monocyte: 409 nTPM
- basophil: 406 nTPM
- non-classical monocyte: 403 nTPM
Brain region
- cerebral cortex: 157 nTPM
- basal ganglia: 144 nTPM
- hypothalamus: 136 nTPM
- hippocampal formation: 134 nTPM
- choroid plexus: 121 nTPM
- cerebellum: 120 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.55
- gnomAD pLI
- 0.81
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- ATP synthase subunit ATP5MJ, mitochondrial
- Mitochondrial proteolipid
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ATP5MJ as an antibody target. Whether an autoantibody or antibody against ATP5MJ could matter depends on whether native ATP5MJ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ATP5MJ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ATP5MJ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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