Seroatlas · Human Serome Atlas

ATP5MGL

ATP synthase subunit g 2, mitochondrial

Also known as: AT5L2_HUMAN, ATP5K2, ATP5L2, dJ222E13.5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z4Y8
Gene: ATP5MGL
Ensembl: ENSG00000249222
Chromosome: 22
Canonical length: 100 aa
Protein class: Predicted membrane proteins
Subcellular location: Mitochondria,Principal piece

OverviewNCBI Gene

Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven ATP synthesis. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

100 residues, UniProt reviewed canonical sequence.

>Q7Z4Y8|ATP5MGL
     1  MAPFVRNLVE KTPALVNAAV TYLKPRLAAF WYYTTVELVP PTPAEIPRAI QSLKKIVSSA
    61  QTGSFKQLTV KEALLNGLVA TEVSTWFYVR EITGKRGIIG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP5MGL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 1.4 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 1.4 nTPM
skin: 0.8 nTPM
epididymis: 0.6 nTPM
retina: 0.5 nTPM
lymph node: 0.4 nTPM
gallbladder: 0.3 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0.9 nTPM
neutrophil: 0.9 nTPM
total PBMC: 0.3 nTPM
classical monocyte: 0.2 nTPM
eosinophil: 0.2 nTPM
memory B-cell: 0.2 nTPM

Brain region

cerebellum: 13 nTPM
cerebral cortex: 9.9 nTPM
medulla oblongata: 9.9 nTPM
hypothalamus: 9 nTPM
thalamus: 8.9 nTPM
white matter: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.96
gnomAD pLI: 0
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proton motive force-driven ATP synthesis

Molecular functions

proton transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATP5MGL as an antibody target. Whether an autoantibody or antibody against ATP5MGL could matter depends on whether native ATP5MGL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATP5MGL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATP5MGL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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