ATP5MC2

Protein identityUniProt · HPA

UniProt accession

Q06055

Gene

ATP5MC2

Ensembl

ENSG00000135390

Chromosome

12

Canonical length

141 aa

Protein class

Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). There are three separate genes which encode subunit c of the proton channel and they specify precursors with different import sequences but identical mature proteins. The protein encoded by this gene is one of three precursors of subunit c. This gene has multiple pseudogenes. [provided by RefSeq, Jan 2018]

Canonical amino-acid sequenceUniProt

141 residues, UniProt reviewed canonical sequence.

>Q06055|ATP5MC2
     1  MFACSKFVST PSLVKSTSQL LSRPLSAVVL KRPEILTDES LSSLAVSCPL TSLVSSRSFQ
    61  TSAISRDIDT AAKFIGAGAA TVGVAGSGAG IGTVFGSLII GYARNPSLKQ QLFSYAILGF
   121  ALSEAMGLFC LMVAFLILFA M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP5MC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

2

Mean surface accessibility (rSASA)

0.54

Highest tissue expression

1,358 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.66

gnomAD pLI

0

DepMap mean gene effect

-0.32

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• proton motive force-driven ATP synthesis

Molecular functions

• lipid binding
• proton transmembrane transporter activity

Cellular components

• mitochondrial inner membrane
• mitochondrion
• proton-transporting ATP synthase complex
• proton-transporting two-sector ATPase complex, proton-transporting domain

Protein domainsUniProt · Pfam · InterPro

• ATP synthase, F0 complex, subunit C
• V-ATPase proteolipid subunit C-like domain
• ATP synthase, F0 complex, subunit C, DCCD-binding site
• F/V-ATP synthase subunit C superfamily
• F1F0 ATP synthase subunit C superfamily
• ATP synthase subunit C

KeywordsUniProt

• CF(0)
• Hydrogen ion transport
• Ion transport
• Lipid-binding
• Membrane
• Methylation
• Mitochondrion
• Transit peptide
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of ATP5MC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DNAJC30