ATP5F1EP2
ATP synthase subunit epsilon-like protein, mitochondrial
Also known as: AT5EL_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for ATP5F1EP2 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
51 residues, UniProt reviewed canonical sequence.
>Q5VTU8|ATP5F1EP2
1 MVAYWRQAGL SYIRYSQICA KVVRDALKTE FKANAKKTSG NSVKIVKVKK ELocalizationUniProt · AlphaFold · HPA
Whether an antibody against ATP5F1EP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ATP5F1EP2 as an antibody target. Whether an autoantibody or antibody against ATP5F1EP2 could matter depends on whether native ATP5F1EP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ATP5F1EP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ATP5F1EP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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