Seroatlas · Human Serome Atlas

ATP4B

Potassium-transporting ATPase subunit beta

Also known as: ATP4B_HUMAN, ATP6B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51164
Gene: ATP4B
Ensembl: ENSG00000186009
Chromosome: 13
Canonical length: 291 aa
Protein class: FDA approved drug targets, Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

291 residues, UniProt reviewed canonical sequence.

>P51164|ATP4B
     1  MAALQEKKTC GQRMEEFQRY CWNPDTGQML GRTLSRWVWI SLYYVAFYVV MTGLFALCLY
    61  VLMQTVDPYT PDYQDQLRSP GVTLRPDVYG EKGLEIVYNV SDNRTWADLT QTLHAFLAGY
   121  SPAAQEDSIN CTSEQYFFQE SFRAPNHTKF SCKFTADMLQ NCSGLADPNF GFEEGKPCFI
   181  IKMNRIVKFL PSNGSAPRVD CAFLDQPREL GQPLQVKYYP PNGTFSLHYF PYYGKKAQPH
   241  YSNPLVAAKL LNIPRNAEVA IVCKVMAEHV TFNNPHDPYE GKVEFKLKIE K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 1,002 nTPM

Expression across tissuesHPA

Tissue

stomach: 1,002 nTPM
choroid plexus: 6.8 nTPM
fallopian tube: 3.1 nTPM
hypothalamus: 0.9 nTPM
hippocampal formation: 0.6 nTPM
amygdala: 0.4 nTPM

Single-cell type

parietal cells: 7,052 nCPM
gastric chief cells: 141 nCPM
mucous neck cells: 16 nCPM
fallopian tube ciliated cells: 13 nCPM
epididymal efferent duct ciliated cells: 11 nCPM
ependymal cells: 9.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 7.9 nTPM
medulla oblongata: 1.4 nTPM
midbrain: 1.3 nTPM
spinal cord: 1.2 nTPM
hippocampal formation: 0.6 nTPM
hypothalamus: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 0.17
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATP4B as an antibody target. Whether an autoantibody or antibody against ATP4B could matter depends on whether native ATP4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATP4B is annotated at the cell surface, where native ATP4B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ATP4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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