Seroatlas · Human Serome Atlas

ATP23

Mitochondrial inner membrane protease ATP23 homolog

Also known as: ATP23_HUMAN, KUB3, XRCC6BP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6H3
Gene: ATP23
Ensembl: ENSG00000166896
Chromosome: 12
Canonical length: 246 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Cell Junctions,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

246 residues, UniProt reviewed canonical sequence.

>Q9Y6H3|ATP23
     1  MAGAPDERRR GPAAGEQLQQ QHVSCQVFPE RLAQGNPQQG FFSSFFTSNQ KCQLRLLKTL
    61  ETNPYVKLLL DAMKHSGCAV NKDRHFSCED CNGNVSGGFD ASTSQIVLCQ NNIHNQAHMN
   121  RVVTHELIHA FDHCRAHVDW FTNIRHLACS EVRAANLSGD CSLVNEIFRL HFGLKQHHQT
   181  CVRDRATLSI LAVRNISKEV AKKAVDEVFE SCFNDHEPFG RIPHNKTYAR YAHRDFENRD
   241  RYYSNI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 6 nTPM

Expression across tissuesHPA

Tissue

testis: 6 nTPM
skeletal muscle: 2.8 nTPM
colon: 1.8 nTPM
adipose tissue: 1.7 nTPM
cerebellum: 1.4 nTPM
esophagus: 1.3 nTPM

Single-cell type

late primary spermatocytes: 83 nCPM
early spermatids: 59 nCPM
late spermatids: 16 nCPM
monocyte progenitors: 12 nCPM
brain excitatory neurons: 12 nCPM
brain inhibitory neurons: 11 nCPM

Immune cell

neutrophil: 1.6 nTPM
memory CD8 T-cell: 0.3 nTPM
naive B-cell: 0.3 nTPM
classical monocyte: 0.2 nTPM
gdT-cell: 0.2 nTPM
intermediate monocyte: 0.2 nTPM

Brain region

hippocampal formation: 5.1 nTPM
cerebral cortex: 5 nTPM
cerebellum: 4.3 nTPM
thalamus: 4.2 nTPM
amygdala: 4.1 nTPM
basal ganglia: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
DepMap mean gene effect: -0.43
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Peptidase M76, ATP23
Peptidase M76 family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATP23 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

XRCC6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATP23 as an antibody target. Whether an autoantibody or antibody against ATP23 could matter depends on whether native ATP23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATP23 is annotated at the cell surface, where native ATP23 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ATP23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...