ATOX1

Protein identityUniProt · HPA

UniProt accession

O00244

Gene

ATOX1

Ensembl

ENSG00000177556

Chromosome

5

Canonical length

68 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Plasma membrane

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

68 residues, UniProt reviewed canonical sequence.

>O00244|ATOX1
     1  MPKHEFSVDM TCGGCAEAVS RVLNKLGGVK YDIDLPNKKV CIESEHSMDT LLATLKKTGK
    61  TVSYLGLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATOX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

407 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.07

gnomAD pLI

0.59

gnomAD missense Z

-0.06

DepMap mean gene effect

0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• copper ion export
• copper ion transport
• intracellular copper ion homeostasis
• negative regulation of apoptotic process
• response to oxidative stress

Molecular functions

• ATPase binding
• copper chaperone activity
• copper ion binding
• copper-dependent protein binding
• cuprous ion binding
• metallochaperone activity

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• Heavy metal-associated domain, HMA
• Heavy-metal-associated, conserved site
• Heavy metal-associated domain superfamily
• Heavy-metal-associated domain
• Copper transport ATOX1-like

KeywordsUniProt

• Acetylation
• Chaperone
• Copper
• Copper transport
• Ion transport
• Metal-binding
• Phosphoprotein
• Transport

InteractionsUniProt · HPA

Protein binding partners of ATOX1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATP7A
• ATP7B