Seroatlas · Human Serome Atlas

ATOSB

Atos homolog protein B

Also known as: ATOSB_HUMAN, bA182N22.6, FAM214B, FLJ11560, KIAA1539

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L5A3
Gene: ATOSB
Ensembl: ENSG00000005238
Chromosome: 9
Canonical length: 538 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

538 residues, UniProt reviewed canonical sequence.

>Q7L5A3|ATOSB
     1  MRHVQAEPSP SSEPEAGPSQ PPVRQGALQG GLLMGYSPAG GATSPGVYQV SIFSPPAGTS
    61  EPHRALKRQA PSTEGPRELK RGPGLGAREG LPPEEPSTVG LLGPEGPGLG LGVASQHFSH
   121  RGLCVVEQRS SVTSSWTSGA WSPPCPPSNA SCNTLHTRDW ASPDPGGQGS LGESPGPAPP
   181  GQLHTLDTDL HSLAQIGGKS PVAGVGNGGS LWPRESPGTA NGHSPEHTPP GPGPPGPCPT
   241  KRRLLPAGEA PDVSSEEEGP APRRRRGSLG HPTAANSSDA KATPFWSHLL PGPKEPVLDP
   301  TDCGPMGRRL KGARRLKLSP LRSLRKGPGL LSPPSASPVP TPAVSRTLLG NFEESLLRGR
   361  FAPSGHIEGF TAEIGASGSY CPQHVTLPVT VTFFDVSEQN APAPFLGIVD LNPLGRKGYS
   421  VPKVGTVQVT LFNPNQTVVK MFLVTFDFSD MPAAHMTFLR HRLFLVPVGE EGNANPTHRL
   481  LCYLLHLRFR SSRSGRLSLH GDIRLLFSRR SLELDTGLPY ELQAVTEAPH NPRYSPLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATOSB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 37 nTPM
spinal cord: 31 nTPM
esophagus: 29 nTPM
blood vessel: 27 nTPM
spleen: 27 nTPM
midbrain: 24 nTPM

Single-cell type

platelets: 197 nCPM
late spermatids: 151 nCPM
esophageal apical cells: 151 nCPM
megakaryocytes: 111 nCPM
neutrophils: 97 nCPM
neutrophil progenitors: 39 nCPM

Immune cell

neutrophil: 16 nTPM
non-classical monocyte: 10 nTPM
intermediate monocyte: 7.7 nTPM
classical monocyte: 5.9 nTPM
eosinophil: 5.7 nTPM
basophil: 5 nTPM

Brain region

thalamus: 37 nTPM
medulla oblongata: 37 nTPM
pons: 34 nTPM
midbrain: 33 nTPM
white matter: 30 nTPM
cerebral cortex: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.8
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATOSB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MDFI

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATOSB as an antibody target. Whether an autoantibody or antibody against ATOSB could matter depends on whether native ATOSB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATOSB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATOSB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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