Seroatlas · Human Serome Atlas

ATOSA

Atos homolog protein A

Also known as: ATOSA_HUMAN, FAM214A, FLJ10980, KIAA1370

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q32MH5
Gene: ATOSA
Ensembl: ENSG00000047346
Chromosome: 15
Canonical length: 1076 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1076 residues, UniProt reviewed canonical sequence.

>Q32MH5|ATOSA
     1  MKPDRDTLDE YFEYDAEEFL VSLALLITEG RTPECSVKGR TESFHCPPAQ SCYPVTTKHE
    61  CSDKLAQCRQ ARRTRSEVTL LWKNNLPIMV EMMLLPDCCY SDDGPTTEGI DLNDPAIKQD
   121  ALLLERWILE PVPRQNGDRF IEEKTLLLAV RSFVFFSQLS AWLSVSHGAI PRNILYRISA
   181  ADVDLQWNFS QTPIEHVFPV PNVSHNVALK VSVQSLPRQS NYPVLTCSIH TNIGLYEKRI
   241  QQHKLKTHQH HNPNEAEQCG TNSSQRLCSK QTWTMAPESV LHAKSGPSPE YTAAVKNIKL
   301  YPGTGSKSDH GTSQANILGF SGIGDIKSQE TSVRTLKSFS MVDSSISNRQ SFWQSAGETN
   361  PLIGSLIQER QEIIARIAQH LIHCDPSTSH VSGRPFNTQE SSSLHSKLFR VSQENENVGK
   421  GKEAFSMTFG SPEFSSPEDT NEGKIRLKPE TPRSETCISN DFYSHMPVGE TNPLIGSLLQ
   481  ERQDVIARIA QHLEHIDPTA SHIPRQSFNM HDSSSVASKV FRSSYEDKNL LKKNKDESSV
   541  SISHTKCSLL GDISDGKNLV PNKCFTSFKN NSKEKCSLKH QTRNQCQNNP SEIIQSTYQE
   601  TQNKSSSLST SSILSQHKEN NLDLTSRFKE QEMSNGIDKQ YSNCTTIDKQ ICTNKYKEKI
   661  INENYNPKFF GNLQSDDSKK NDSKIKVTVL EMSEYLNKYE SMSSNKDSKR PKTCEQNTQL
   721  NSIENYLNKD NEGFKCKKSD QLKNEQDKQE DPTNEKSQNY SQRRSIKDCL STCEQPKNTE
   781  VLRTTLKHSN VWRKHNFHSL DGTSTRAFHP QTGLPLLSSP VPQRKTQSGC FDLDSSLLHL
   841  KSFSSRSPRP CLNIEDDPDI HEKPFLSSSA PPITSLSLLG NFEESVLNYR FDPLGIVDGF
   901  TAEVGASGAF CPTHLTLPVE VSFYSVSDDN APSPYMGVIT LESLGKRGYR VPPSGTIQVT
   961  LFNPNKTVVK MFVVIYDLRD MPANHQTFLR QRTFSVPVKQ EVKRSVNKEN IRHTEERLLR
  1021  YLIHLRFQSS KSGKIYLHRD VRLLFSRKSM EVDSGAAYEL KSYTESPTNP QFSPRC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATOSA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 43 nTPM
parathyroid gland: 38 nTPM
liver: 35 nTPM
adipose tissue: 30 nTPM
tonsil: 28 nTPM
esophagus: 26 nTPM

Single-cell type

myonuclei: 724 nCPM
endometrial glandular cells: 663 nCPM
esophageal apical cells: 518 nCPM
adipocytes: 472 nCPM
thyrotrophs: 410 nCPM
thymic myoid cells: 375 nCPM

Immune cell

plasmacytoid DC: 8.2 nTPM
memory B-cell: 6.4 nTPM
eosinophil: 5.5 nTPM
naive B-cell: 5.5 nTPM
NK-cell: 5.1 nTPM
T-reg: 4.9 nTPM

Brain region

choroid plexus: 103 nTPM
cerebellum: 67 nTPM
white matter: 43 nTPM
basal ganglia: 41 nTPM
pons: 39 nTPM
thalamus: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.45
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Nucleus

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATOSA as an antibody target. Whether an autoantibody or antibody against ATOSA could matter depends on whether native ATOSA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATOSA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATOSA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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