Seroatlas · Human Serome Atlas

ATF6B

Cyclic AMP-dependent transcription factor ATF-6 beta

Also known as: ATF6B_HUMAN, CREBL1, G13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99941
Gene: ATF6B
Ensembl: ENSG00000213676
Chromosome: 6
Canonical length: 703 aa
Protein class: Plasma proteins, Predicted membrane proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

703 residues, UniProt reviewed canonical sequence.

>Q99941|ATF6B
     1  MAELMLLSEI ADPTRFFTDN LLSPEDWGLQ NSTLYSGLDE VAEEQTQLFR CPEQDVPFDG
    61  SSLDVGMDVS PSEPPWELLP IFPDLQVKSE PSSPCSSSSL SSESSRLSTE PSSEALGVGE
   121  VLHVKTESLA PPLCLLGDDP TSSFETVQIN VIPTSDDSSD VQTKIEPVSP CSSVNSEASL
   181  LSADSSSQAF IGEEVLEVKT ESLSPSGCLL WDVPAPSLGA VQISMGPSLD GSSGKALPTR
   241  KPPLQPKPVV LTTVPMPSRA VPPSTTVLLQ SLVQPPPVSP VVLIQGAIRV QPEGPAPSLP
   301  RPERKSIVPA PMPGNSCPPE VDAKLLKRQQ RMIKNRESAC QSRRKKKEYL QGLEARLQAV
   361  LADNQQLRRE NAALRRRLEA LLAENSELKL GSGNRKVVCI MVFLLFIAFN FGPVSISEPP
   421  SAPISPRMNK GEPQPRRHLL GFSEQEPVQG VEPLQGSSQG PKEPQPSPTD QPSFSNLTAF
   481  PGGAKELLLR DLDQLFLSSD CRHFNRTESL RLADELSGWV QRHQRGRRKI PQRAQERQKS
   541  QPRKKSPPVK AVPIQPPGPP ERDSVGQLQL YRHPDRSQPA FLDAIDRRED TFYVVSFRRD
   601  HLLLPAISHN KTSRPKMSLV MPAMAPNETL SGRGAPGDYE EMMQIECEVM DTRVIHIKTS
   661  TVPPSLRKQP SPTPGNATGG PLPVSAASQA HQASHQPLYL NHP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATF6B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

spleen: 55 nTPM
esophagus: 52 nTPM
ovary: 51 nTPM
skin: 48 nTPM
cervix: 46 nTPM
thyroid gland: 46 nTPM

Single-cell type

bergmann glia: 37 nCPM
renal collecting duct principal cells: 34 nCPM
brain inhibitory neurons: 31 nCPM
distal convoluted tubule cells: 31 nCPM
papillary tip epithelial cells: 30 nCPM
proximal tubule cells: 28 nCPM

Immune cell

basophil: 4.2 nTPM
NK-cell: 2.5 nTPM
myeloid DC: 2.3 nTPM
total PBMC: 2.2 nTPM
gdT-cell: 1.9 nTPM
T-reg: 1.8 nTPM

Brain region

hypothalamus: 14 nTPM
cerebral cortex: 12 nTPM
midbrain: 12 nTPM
pons: 12 nTPM
thalamus: 11 nTPM
amygdala: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0
gnomAD missense Z: 1.53
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATF6B as an antibody target. Whether an autoantibody or antibody against ATF6B could matter depends on whether native ATF6B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATF6B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATF6B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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