Seroatlas · Human Serome Atlas

ASRGL1

Isoaspartyl peptidase/L-asparaginase

Also known as: ALP, ALP1, ASGL1_HUMAN, FLJ22316

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L266
Gene: ASRGL1
Ensembl: ENSG00000162174
Chromosome: 11
Canonical length: 308 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Microtubules,Cytokinetic bridge

OverviewNCBI Gene

Enables asparaginase activity and beta-aspartyl-peptidase activity. Involved in asparagine catabolic process via L-aspartate. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

308 residues, UniProt reviewed canonical sequence.

>Q7L266|ASRGL1
     1  MNPIVVVHGG GAGPISKDRK ERVHQGMVRA ATVGYGILRE GGSAVDAVEG AVVALEDDPE
    61  FNAGCGSVLN TNGEVEMDAS IMDGKDLSAG AVSAVQCIAN PIKLARLVME KTPHCFLTDQ
   121  GAAQFAAAMG VPEIPGEKLV TERNKKRLEK EKHEKGAQKT DCQKNLGTVG AVALDCKGNV
   181  AYATSTGGIV NKMVGRVGDS PCLGAGGYAD NDIGAVSTTG HGESILKVNL ARLTLFHIEQ
   241  GKTVEEAADL SLGYMKSRVK GLGGLIVVSK TGDWVAKWTS TSMPWAAAKD GKLHFGIDPD
   301  DTTITDLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASRGL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.21
Highest tissue expression: 124 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 124 nTPM
cervix: 114 nTPM
midbrain: 103 nTPM
testis: 94 nTPM
amygdala: 88 nTPM
cerebral cortex: 85 nTPM

Single-cell type

late primary spermatocytes: 1,172 nCPM
late spermatids: 894 nCPM
epididymal efferent duct absorptive cells: 668 nCPM
endometrial luminal cells: 518 nCPM
fallopian tube ciliated cells: 478 nCPM
endometrial glandular cells: 452 nCPM

Immune cell

basophil: 279 nTPM
eosinophil: 270 nTPM
classical monocyte: 69 nTPM
intermediate monocyte: 51 nTPM
myeloid DC: 40 nTPM
non-classical monocyte: 39 nTPM

Brain region

thalamus: 114 nTPM
midbrain: 92 nTPM
cerebral cortex: 87 nTPM
basal ganglia: 75 nTPM
amygdala: 73 nTPM
hypothalamus: 71 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.39
gnomAD pLI: 0
gnomAD missense Z: 0.2
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis
L-asparagine catabolic process via L-aspartate

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASRGL1 as an antibody target. Whether an autoantibody or antibody against ASRGL1 could matter depends on whether native ASRGL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASRGL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASRGL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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