ASPG

Protein identityUniProt · HPA

UniProt accession

Q86U10

Gene

ASPG

Ensembl

ENSG00000166183

Chromosome

14

Canonical length

573 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups; asparaginase activity; and lysophospholipase activity. Predicted to be involved in asparagine metabolic process and phospholipid metabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

573 residues, UniProt reviewed canonical sequence.

>Q86U10|ASPG
     1  MARAVGPERR LLAVYTGGTI GMRSELGVLV PGTGLAAILR TLPMFHDEEH ARARGLSEDT
    61  LVLPPASRNQ RILYTVLECQ PLFDSSDMTI AEWVCLAQTI KRHYEQYHGF VVIHGTDTMA
   121  FAASMLSFML ENLQKTVILT GAQVPIHALW SDGRENLLGA LLMAGQYVIP EVCLFFQNQL
   181  FRGNRATKVD ARRFAAFCSP NLLPLATVGA DITINRELVR KVDGKAGLVV HSSMEQDVGL
   241  LRLYPGIPAA LVRAFLQPPL KGVVMETFGS GNGPTKPDLL QELRVATERG LVIVNCTHCL
   301  QGAVTTDYAA GMAMAGAGVI SGFDMTSEAA LAKLSYVLGQ PGLSLDVRKE LLTKDLRGEM
   361  TPPSVEERRP SLQGNTLGGG VSWLLSLSGS QEADALRNAL VPSLACAAAH AGDVEALQAL
   421  VELGSDLGLV DFNGQTPLHA AARGGHTEAV TMLLQRGVDV NTRDTDGFSP LLLAVRGRHP
   481  GVIGLLREAG ASLSTQELEE AGTELCRLAY RADLEGLQVW WQAGADLGQP GYDGHSALHV
   541  AEAAGNLAVV AFLQSLEGAV GAQAPCPEVL PGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASPG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

143 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.14

gnomAD pLI

0

gnomAD missense Z

0.95

DepMap mean gene effect

0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• L-amino acid metabolic process
• lipid catabolic process
• aspartate family amino acid metabolic process

Molecular functions

• 1-alkyl-2-acetylglycerophosphocholine esterase activity
• acyltransferase activity, transferring groups other than amino-acyl groups
• asparaginase activity
• phosphatidylcholine lysophospholipase activity

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• Ankyrin repeat
• Ankyrin repeat-containing domain superfamily
• Ankyrin repeats (3 copies)
• Type I L-asparaginase family
• Asparaginase/glutaminase-like
• L-asparaginase, C-terminal
• L-asparaginase, N-terminal
• Asparaginase/glutaminase, active site 2
• Asparaginase/glutaminase-like superfamily
• L-asparaginase, N-terminal domain superfamily
• Asparaginase/glutaminase, C-terminal
• Type I (cytosolic) L-asparaginase
• Asparaginase, N-terminal
• Glutaminase/Asparaginase C-terminal domain

KeywordsUniProt

• Acyltransferase
• ANK repeat
• Hydrolase
• Lipid degradation
• Lipid metabolism
• Repeat
• Transferase