Seroatlas · Human Serome Atlas

ASIP

Agouti-signaling protein

Also known as: AGTIL, ASIP_HUMAN, ASP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P42127
Gene: ASIP
Ensembl: ENSG00000101440
Chromosome: 20
Canonical length: 132 aa
Protein class: Predicted secreted proteins
Subcellular location: Vesicles,Flagellar centriole,Mid piece
Secretome location: Secreted to blood

OverviewNCBI Gene

In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

132 residues, UniProt reviewed canonical sequence.

>P42127|ASIP
     1  MDVTRLLLAT LLVFLCFFTA NSHLPPEEKL RDDRSLRSNS SVNLLDVPSV SIVALNKKSK
    61  QIGRKAAEKK RSSKKEASMK KVVRPRTPLS APCVATRNSC KPPAPACCDP CASCQCRFFR
   121  SACSCRVLSL NC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

ovary: 35 nTPM
heart muscle: 23 nTPM
epididymis: 12 nTPM
skin: 5 nTPM
cervix: 3.4 nTPM
fallopian tube: 2.6 nTPM

Single-cell type

ovarian stromal cells: 139 nCPM
decidual stromal cells: 92 nCPM
epididymal principal cells: 86 nCPM
pdcs: 53 nCPM
epicardial cells: 46 nCPM
peritubular myoid cells: 41 nCPM

Immune cell

plasmacytoid DC: 126 nTPM
total PBMC: 0.6 nTPM
naive B-cell: 0.3 nTPM
memory B-cell: 0.2 nTPM
myeloid DC: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM

Brain region

pons: 3.6 nTPM
basal ganglia: 3.5 nTPM
cerebral cortex: 3.3 nTPM
white matter: 3.1 nTPM
hypothalamus: 3 nTPM
medulla oblongata: 2.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ASIP.

Disease | AllUniProt

Conditions ASIP is implicated in, by any mechanism.

Obesity and hypopigmentation (OBHP) MIM:620195

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0.02
gnomAD missense Z: 0.12
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASIP as an antibody target. Whether an autoantibody or antibody against ASIP could matter depends on whether native ASIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASIP is annotated as secreted, so native ASIP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ASIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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