Seroatlas · Human Serome Atlas

ASIC4

Acid-sensing ion channel 4

Also known as: ACCN4, ASIC4_HUMAN, BNAC4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96FT7
Gene
ASIC4
Ensembl
ENSG00000072182
Chromosome
2
Canonical length
539 aa
Protein class
Predicted membrane proteins
Subcellular location
Golgi apparatus
Quaternary structure
Homotrimer

OverviewNCBI Gene

This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

539 residues, UniProt reviewed canonical sequence.

>Q96FT7|ASIC4
     1  MPIEIVCKIK FAEEDAKPKE KEAGDEQSLL GAVAPGAAPR DLATFASTST LHGLGRACGP
    61  GPHGLRRTLW ALALLTSLAA FLYQAAGLAR GYLTRPHLVA MDPAAPAPVA GFPAVTLCNI
   121  NRFRHSALSD ADIFHLANLT GLPPKDRDGH RAAGLRYPEP DMVDILNRTG HQLADMLKSC
   181  NFSGHHCSAS NFSVVYTRYG KCYTFNADPR SSLPSRAGGM GSGLEIMLDI QQEEYLPIWR
   241  ETNETSFEAG IRVQIHSQEE PPYIHQLGFG VSPGFQTFVS CQEQRLTYLP QPWGNCRAES
   301  ELREPELQGY SAYSVSACRL RCEKEAVLQR CHCRMVHMPG NETICPPNIY IECADHTLDS
   361  LGGGPEGPCF CPTPCNLTRY GKEISMVRIP NRGSARYLAR KYNRNETYIR ENFLVLDVFF
   421  EALTSEAMEQ RAAYGLSALL GDLGGQMGLF IGASILTLLE ILDYIYEVSW DRLKRVWRRP
   481  KTPLRTSTGG ISTLGLQELK EQSPCPSRGR VEGGGVSSLL PNHHHPHGPP GGLFEDFAC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASIC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
7.4 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 7.4 nTPM
  • retina: 6 nTPM
  • cerebral cortex: 5.9 nTPM
  • amygdala: 4.9 nTPM
  • hypothalamus: 4.3 nTPM
  • midbrain: 4.2 nTPM

Single-cell type

  • retinal bipolar cells: 172 nCPM
  • lactotrophs: 98 nCPM
  • oligodendrocyte progenitor cells: 73 nCPM
  • cone photoreceptor cells: 64 nCPM
  • corticotrophs: 57 nCPM
  • thyrotrophs: 33 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 19 nTPM
  • cerebral cortex: 17 nTPM
  • midbrain: 14 nTPM
  • amygdala: 8.9 nTPM
  • spinal cord: 8.1 nTPM
  • medulla oblongata: 7.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0
gnomAD missense Z
0.75
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASIC4 as an antibody target. Whether an autoantibody or antibody against ASIC4 could matter depends on whether native ASIC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASIC4 is annotated at the cell surface, where native ASIC4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ASIC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ASIC4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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