Seroatlas · Human Serome Atlas

ASCL2

Achaete-scute homolog 2

Also known as: ASCL2_HUMAN, ASH2, bHLHa45, HASH2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99929
Gene: ASCL2
Ensembl: ENSG00000183734
Chromosome: 11
Canonical length: 193 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>Q99929|ASCL2
     1  MDGGTLPRSA PPAPPVPVGC AARRRPASPE LLRCSRRRRP ATAETGGGAA AVARRNERER
    61  NRVKLVNLGF QALRQHVPHG GASKKLSKVE TLRSAVEYIR ALQRLLAEHD AVRNALAGGL
   121  RPQAVRPSAP RGPPGTTPVA ASPSRASSSP GRGGSSEPGS PRSAYSSDDS GCEGALSPAE
   181  RELLDFSSWL GGY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASCL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 8 nTPM

Expression across tissuesHPA

Tissue

skin: 8 nTPM
salivary gland: 7.6 nTPM
duodenum: 6.5 nTPM
placenta: 5.2 nTPM
small intestine: 5.2 nTPM
colon: 3.6 nTPM

Single-cell type

extravillous trophoblasts: 1,529 nCPM
paneth cells: 232 nCPM
enteric stem cells: 221 nCPM
migrating cytotrophoblasts: 161 nCPM
enteric transient amplifying cells: 59 nCPM
tuft cells: 58 nCPM

Immune cell

eosinophil: 7.9 nTPM
basophil: 3.9 nTPM
gdT-cell: 2.2 nTPM
intermediate monocyte: 1.7 nTPM
non-classical monocyte: 1.4 nTPM
memory CD8 T-cell: 1.3 nTPM

Brain region

white matter: 4.8 nTPM
midbrain: 4 nTPM
medulla oblongata: 3.5 nTPM
thalamus: 3.1 nTPM
spinal cord: 2.3 nTPM
amygdala: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.82
gnomAD pLI: 0.35
gnomAD missense Z: 0.56
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASCL2 as an antibody target. Whether an autoantibody or antibody against ASCL2 could matter depends on whether native ASCL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASCL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASCL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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