ASAH2B
Putative inactive neutral ceramidase B
Also known as: ASA2B_HUMAN, ASAH2C, ASAH2L, bA449O16.3, bA98I6.3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0C7U1
- Gene
- ASAH2B
- Ensembl
- ENSG00000204147
- Chromosome
- 10
- Canonical length
- 165 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Focal adhesion sites
OverviewNCBI Gene
Predicted to enable N-acylsphingosine amidohydrolase activity. Predicted to be involved in ceramide catabolic process. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
165 residues, UniProt reviewed canonical sequence.
>P0C7U1|ASAH2B
1 MRQHRQFMDR THYLLTFSSS ETLLRLLLRI VDRAPKGRTF GDVLQPAKPE YRVGEVAEVI
61 FVGANPKNSV QNQTHQTFLT VEKYEATSTS WQIVCNDASW ETRFYWHKGL LGLSNATVEW
121 HIPDTAQPGI YRIRYFGHNR KQDILKPAVI LSFEGTSPAF EVVTILocalizationUniProt · AlphaFold · HPA
Whether an antibody against ASAH2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 14 nTPM
Expression across tissuesHPA
Tissue
- duodenum: 14 nTPM
- small intestine: 9.3 nTPM
- retina: 6.3 nTPM
- liver: 5.7 nTPM
- heart muscle: 4.9 nTPM
- kidney: 4.1 nTPM
Single-cell type
- cone photoreceptor cells: 35 nCPM
- lactotrophs: 26 nCPM
- myonuclei: 25 nCPM
- podocytes: 21 nCPM
- somatotrophs: 21 nCPM
- rod photoreceptor cells: 20 nCPM
Immune cell
- MAIT T-cell: 3.2 nTPM
- naive CD4 T-cell: 2.6 nTPM
- naive CD8 T-cell: 2.5 nTPM
- T-reg: 2.4 nTPM
- memory CD4 T-cell: 1.9 nTPM
- plasmacytoid DC: 1.9 nTPM
Brain region
- white matter: 11 nTPM
- hypothalamus: 10 nTPM
- cerebral cortex: 9.9 nTPM
- medulla oblongata: 9.9 nTPM
- midbrain: 9.6 nTPM
- pons: 9.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.7
- gnomAD pLI
- 0.16
- gnomAD missense Z
- 0.76
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ASAH2B as an antibody target. Whether an autoantibody or antibody against ASAH2B could matter depends on whether native ASAH2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ASAH2B is annotated at the cell surface, where native ASAH2B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label ASAH2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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