Seroatlas · Human Serome Atlas

AS3MT

Arsenite methyltransferase

Also known as: AS3MT_HUMAN, CYT19

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HBK9
Gene: AS3MT
Ensembl: ENSG00000214435
Chromosome: 10
Canonical length: 375 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>Q9HBK9|AS3MT
     1  MAALRDAEIQ KDVQTYYGQV LKRSADLQTN GCVTTARPVP KHIREALQNV HEEVALRYYG
    61  CGLVIPEHLE NCWILDLGSG SGRDCYVLSQ LVGEKGHVTG IDMTKGQVEV AEKYLDYHME
   121  KYGFQASNVT FIHGYIEKLG EAGIKNESHD IVVSNCVINL VPDKQQVLQE AYRVLKHGGE
   181  LYFSDVYTSL ELPEEIRTHK VLWGECLGGA LYWKELAVLA QKIGFCPPRL VTANLITIQN
   241  KELERVIGDC RFVSATFRLF KHSKTGPTKR CQVIYNGGIT GHEKELMFDA NFTFKEGEIV
   301  EVDEETAAIL KNSRFAQDFL IRPIGEKLPT SGGCSALELK DIITDPFKLA EESDSMKSRC
   361  VPDAAGGCCG TKKSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AS3MT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 261 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 261 nTPM
parathyroid gland: 53 nTPM
liver: 44 nTPM
heart muscle: 24 nTPM
spleen: 16 nTPM
kidney: 14 nTPM

Single-cell type

choroid plexus epithelial cells: 23 nCPM
ependymal cells: 16 nCPM
brain excitatory neurons: 14 nCPM
astrocytes: 14 nCPM
brain inhibitory neurons: 14 nCPM
other brain neurons: 13 nCPM

Immune cell

NK-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 20 nTPM
choroid plexus: 16 nTPM
hypothalamus: 14 nTPM
midbrain: 14 nTPM
white matter: 14 nTPM
pons: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: 0.96
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

arsenite methyltransferase activity

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

Methyltransferase domain
S-adenosyl-L-methionine-dependent methyltransferase superfamily
Methyltransferase domain
Arsenite methyltransferase-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AS3MT as an antibody target. Whether an autoantibody or antibody against AS3MT could matter depends on whether native AS3MT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AS3MT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AS3MT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...