Seroatlas · Human Serome Atlas

ART5

Ecto-ADP-ribosyltransferase 5

Also known as: ARTC5, NAR5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96L15
Gene: ART5
Ensembl: ENSG00000167311
Chromosome: 11
Canonical length: 291 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

The protein encoded by this gene belongs to the ARG-specific ADP-ribosyltransferase family. Proteins in this family regulate the function of target proteins by attaching ADP-ribose to specific amino acid residues in their target proteins. The mouse homolog lacks a glycosylphosphatidylinositol-anchor signal sequence and is predicted to be a secretory enzyme. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

291 residues, UniProt reviewed canonical sequence.

>Q96L15|ART5
     1  MALAALMIAL GSLGLHTWQA QAVPILPLGL APDTFDDTYV GCAEEMEEKA APLLKEEMAH
    61  HALLRESWEA AQETWEDKRR GLTLPPGFKA QNGIAIMVYT NSSNTLYWEL NQAVRTGGGS
   121  RELYMRHFPF KALHFYLIRA LQLLRGSGGC SRGPGEVVFR GVGSLRFEPK RLGDSVRLGQ
   181  FASSSLDKAV AHRFGNATLF SLTTCFGAPI QAFSVFPKER EVLIPPHEVF LVTRFSQDGA
   241  QSLVTLWSYN QTCSHFNCAY LGGEKRRGCV SAPGALGTGD LHMTKRHLQQ P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ART5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

testis: 29 nTPM
skeletal muscle: 13 nTPM
ovary: 11 nTPM
tongue: 9.8 nTPM
cervix: 4.3 nTPM
endometrium: 3 nTPM

Single-cell type

late primary spermatocytes: 118 nCPM
oocytes: 28 nCPM
late spermatids: 21 nCPM
early spermatids: 14 nCPM
early primary spermatocytes: 11 nCPM
ovarian stromal cells: 10 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 1.3 nTPM
choroid plexus: 0.9 nTPM
pons: 0.7 nTPM
cerebral cortex: 0.4 nTPM
medulla oblongata: 0.3 nTPM
thalamus: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: -0.6
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ART5 as an antibody target. Whether an autoantibody or antibody against ART5 could matter depends on whether native ART5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ART5 is annotated as secreted, so native ART5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ART5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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