Seroatlas · Human Serome Atlas

ART3

Ecto-ADP-ribosyltransferase 3

Also known as: ARTC3, NAR3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13508
Gene: ART3
Ensembl: ENSG00000156219
Chromosome: 4
Canonical length: 389 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Principal piece,End piece
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>Q13508|ART3
     1  MKTGHFEIVT MLLATMILVD IFQVKAEVLD MADNAFDDEY LKCTDRMEIK YVPQLLKEEK
    61  ASHQQLDTVW ENAKAKWAAR KTQIFLPMNF KDNHGIALMA YISEAQEQTP FYHLFSEAVK
   121  MAGQSREDYI YGFQFKAFHF YLTRALQLLR KPCEASSKTV VYRTSQGTSF TFGGLNQARF
   181  GHFTLAYSAK PQAANDQLTV LSIYTCLGVD IENFLDKESE RITLIPLNEV FQVSQEGAGN
   241  NLILQSINKT CSHYECAFLG GLKTENCIEN LEYFQPIYVY NPGEKNQKLE DHSEKNWKLE
   301  DHGEKNQKLE DHGVKILEPT QIPGMKIPEP FPLPEDKSQG NINNPTPGPV PVPGPKSHPS
   361  ASSGKLLLPQ FGMVIILISV SAINLFVAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ART3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 191 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 191 nTPM
testis: 86 nTPM
tongue: 71 nTPM
heart muscle: 64 nTPM
cerebellum: 10 nTPM
blood vessel: 9.4 nTPM

Single-cell type

myonuclei: 528 nCPM
thymic myoid cells: 504 nCPM
early primary spermatocytes: 267 nCPM
late primary spermatocytes: 183 nCPM
choroid plexus epithelial cells: 86 nCPM
cardiomyocytes: 76 nCPM

Immune cell

gdT-cell: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 8.4 nTPM
cerebral cortex: 7.5 nTPM
cerebellum: 5.1 nTPM
hypothalamus: 4.2 nTPM
basal ganglia: 2.5 nTPM
choroid plexus: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: 0.15
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ART3 as an antibody target. Whether an autoantibody or antibody against ART3 could matter depends on whether native ART3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ART3 is annotated at the cell surface, where native ART3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ART3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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