Seroatlas · Human Serome Atlas

ART1

GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1

Also known as: ART2, ARTC1, CD296, NAR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P52961
Gene: ART1
Ensembl: ENSG00000129744
Chromosome: 11
Canonical length: 327 aa
Protein class: CD markers, Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>P52961|ART1
     1  MQMPAMMSLL LVSVGLMEAL QAQSHPITRR DLFSQEIQLD MALASFDDQY AGCAAAMTAA
    61  LPDLNHTEFQ ANQVYADSWT LASSQWQERQ ARWPEWSLSP TRPSPPPLGF RDEHGVALLA
   121  YTANSPLHKE FNAAVREAGR SRAHYLHHFS FKTLHFLLTE ALQLLGSGQR PPRCHQVFRG
   181  VHGLRFRPAG PRATVRLGGF ASASLKHVAA QQFGEDTFFG IWTCLGAPIK GYSFFPGEEE
   241  VLIPPFETFQ VINASRLAQG PARIYLRALG KHSTYNCEYI KDKKCKSGPC HLDNSAMGQS
   301  PLSAVWSLLL LLWFLVVRAF PDGPGLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ART1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 44 nTPM
tongue: 34 nTPM
esophagus: 0.7 nTPM
lung: 0.3 nTPM
prostate: 0.2 nTPM
heart muscle: 0.1 nTPM

Single-cell type

myonuclei: 90 nCPM
thymic myoid cells: 25 nCPM
thymocytes: 3.4 nCPM
medullary thymic epithelial cells: 2.4 nCPM
epicardial cells: 2.3 nCPM
cardiomyocytes: 2.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.1 nTPM
amygdala: 0.8 nTPM
cerebellum: 0.8 nTPM
medulla oblongata: 0.8 nTPM
midbrain: 0.8 nTPM
hippocampal formation: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0
gnomAD missense Z: -0.71
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ART1 as an antibody target. Whether an autoantibody or antibody against ART1 could matter depends on whether native ART1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ART1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ART1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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