ARMT1
Damage-control phosphatase ARMT1
Also known as: ARMT1_HUMAN, C6orf211, FLJ12910
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H993
- Gene
- ARMT1
- Ensembl
- ENSG00000146476
- Chromosome
- 6
- Canonical length
- 441 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nuclear bodies,Cytosol
OverviewNCBI Gene
Enables S-adenosylmethionine-dependent methyltransferase activity; enzyme binding activity; and protein carboxyl O-methyltransferase activity. Involved in DNA damage response. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
441 residues, UniProt reviewed canonical sequence.
>Q9H993|ARMT1
1 MAVVPASLSG QDVGSFAYLT IKDRIPQILT KVIDTLHRHK SEFFEKHGEE GVEAEKKAIS
61 LLSKLRNELQ TDKPFIPLVE KFVDTDIWNQ YLEYQQSLLN ESDGKSRWFY SPWLLVECYM
121 YRRIHEAIIQ SPPIDYFDVF KESKEQNFYG SQESIIALCT HLQQLIRTIE DLDENQLKDE
181 FFKLLQISLW GNKCDLSLSG GESSSQNTNV LNSLEDLKPF ILLNDMEHLW SLLSNCKKTR
241 EKASATRVYI VLDNSGFELV TDLILADFLL SSELATEVHF YGKTIPWFVS DTTIHDFNWL
301 IEQVKHSNHK WMSKCGADWE EYIKMGKWVY HNHIFWTLPH EYCAMPQVAP DLYAELQKAH
361 LILFKGDLNY RKLTGDRKWE FSVPFHQALN GFHPAPLCTI RTLKAEIQVG LQPGQGEQLL
421 ASEPSWWTTG KYGIFQYDGP LLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ARMT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.22
- Highest tissue expression
- 39 nTPM
Expression across tissuesHPA
Tissue
- kidney: 39 nTPM
- liver: 35 nTPM
- thyroid gland: 26 nTPM
- breast: 23 nTPM
- tongue: 21 nTPM
- placenta: 21 nTPM
Single-cell type
- alveolar cells type 2: 75 nCPM
- hepatocytes: 55 nCPM
- breast hormone-responsive cells: 54 nCPM
- extravillous trophoblasts: 50 nCPM
- hofbauer cells: 49 nCPM
- kupffer cells: 49 nCPM
Immune cell
- basophil: 54 nTPM
- eosinophil: 52 nTPM
- intermediate monocyte: 35 nTPM
- non-classical monocyte: 34 nTPM
- classical monocyte: 27 nTPM
- T-reg: 25 nTPM
Brain region
- hypothalamus: 13 nTPM
- cerebral cortex: 12 nTPM
- spinal cord: 12 nTPM
- cerebellum: 12 nTPM
- basal ganglia: 11 nTPM
- pons: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.01
- gnomAD pLI
- 0
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- selective
OntologyGO
Biological processes
Molecular functions
- enzyme binding
- fructose-1-phosphatase activity
- metal ion binding
- phosphatase activity
- S-adenosylmethionine-dependent methyltransferase activity
- fructose 6-phosphate aldolase activity
- protein carboxyl O-methyltransferase activity
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ARMT1 as an antibody target. Whether an autoantibody or antibody against ARMT1 could matter depends on whether native ARMT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ARMT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ARMT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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