Seroatlas · Human Serome Atlas

ARMH2

Armadillo-like helical domain-containing protein 2

Also known as: ARMD2_HUMAN, C6orf229

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
H3BNL8
Gene
ARMH2
Ensembl
ENSG00000260286
Chromosome
6
Canonical length
230 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ARMH2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

230 residues, UniProt reviewed canonical sequence.

>H3BNL8|ARMH2
     1  MANSRFSCTQ IWVKMYGYFA GLCRRLQKFW RVTVKGFFVK KKEKKIPSAE TYFHEEKIVV
    61  LGQVLMNESL PIEKRAQAAQ KIGLLAFTGG PPAGNFAAEY MEEVAHLLQD EELAPKIKIL
   121  LLQSVACWCY LNPVSQKRAK SLQFIPILIS FFEGRFESTI KSETNSYLLL KFWTCYVLSV
   181  MTCNNLSCVK ELKDHSALKY HLQMLAAENW SGWTENFAEV LYFLIGFHRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARMH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • testis: 13 nTPM
  • lung: 1 nTPM
  • choroid plexus: 0.9 nTPM
  • fallopian tube: 0.6 nTPM
  • spleen: 0.6 nTPM
  • lymph node: 0.2 nTPM

Single-cell type

  • late primary spermatocytes: 49 nCPM
  • early spermatids: 20 nCPM
  • respiratory ciliated cells: 6.4 nCPM
  • neutrophils: 4.1 nCPM
  • late spermatids: 3.9 nCPM
  • fallopian tube ciliated cells: 1.5 nCPM

Immune cell

  • neutrophil: 2.5 nTPM
  • MAIT T-cell: 0.7 nTPM
  • naive B-cell: 0.7 nTPM
  • memory B-cell: 0.5 nTPM
  • memory CD8 T-cell: 0.5 nTPM
  • naive CD4 T-cell: 0.5 nTPM

Brain region

  • cerebellum: 0.8 nTPM
  • cerebral cortex: 0.5 nTPM
  • white matter: 0.5 nTPM
  • basal ganglia: 0.4 nTPM
  • choroid plexus: 0.4 nTPM
  • hippocampal formation: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.51
gnomAD pLI
0.07
DepMap mean gene effect
0.1
DepMap dependency class
none

Protein domainsUniProt · Pfam · InterPro

  • Armadillo-like helical domain-containing protein 2
  • Armadillo-like helical domain-containing protein 2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARMH2 as an antibody target. Whether an autoantibody or antibody against ARMH2 could matter depends on whether native ARMH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARMH2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARMH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARMH2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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