Seroatlas · Human Serome Atlas

ARMH1

Armadillo-like helical domain containing protein 1

Also known as: ARMD1_HUMAN, C1orf228, MGC33556, NCRNA00082, p40

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PIY5
Gene: ARMH1
Ensembl: ENSG00000198520
Chromosome: 1
Canonical length: 440 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

440 residues, UniProt reviewed canonical sequence.

>Q6PIY5|ARMH1
     1  MTSIKEQAAI SRLLSFLQEW DNAGKVARSH ILDKFIETNQ GKTAPELEQE FSQGASLFLV
    61  RLTTSLRITY MTDSCLEKLL RSIGIFLSAV SSNRYLIEFL EVGGVLTLLE ILGLEKIKEE
   121  AKKESVKLLQ VIANSGRTYK ELICESYGVR SIAEFLAKSK SEETQEEVQV LLDSLVHGNP
   181  KYQNQVYKGL IALLPCESPK AQQLSLQTLR TAQPIIGTTH PSIVDCVLKV LGTMHLEVQY
   241  EAIELIKDLV GYDVRQALLK GLVALLIPSV KEISKLQAKI LSDPSVLQLT PSLPMFLQQA
   301  AAAKAIGVLA RNDMSIAEEL LYLRVVRGLM AAMGNTDHSN SQRLASLTLE CFVQMFPLVA
   361  EHVRKCMGEE LYQLFLSNAE DLYMKIDSIQ ADILAANTVN VTKALCLHGS SYSMNTLYGS
   421  RDSAQMAYLT HFEEDVESKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARMH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

testis: 11 nTPM
fallopian tube: 7.7 nTPM
liver: 3.9 nTPM
retina: 3.9 nTPM
epididymis: 3.3 nTPM
choroid plexus: 2.9 nTPM

Single-cell type

respiratory ciliated cells: 239 nCPM
ependymal cells: 226 nCPM
choroid plexus epithelial cells: 127 nCPM
astrocytes: 121 nCPM
late spermatids: 91 nCPM
thymocytes: 87 nCPM

Immune cell

basophil: 8.8 nTPM
eosinophil: 6.1 nTPM
plasmacytoid DC: 4.8 nTPM
classical monocyte: 2.1 nTPM
naive CD4 T-cell: 1.6 nTPM
naive CD8 T-cell: 1.6 nTPM

Brain region

choroid plexus: 11 nTPM
midbrain: 11 nTPM
medulla oblongata: 7.6 nTPM
hippocampal formation: 6.7 nTPM
white matter: 6.5 nTPM
cerebral cortex: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo-like helical
Armadillo-type fold
Protein of unknown function DUF5578
Family of unknown function (DUF5578)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARMH1 as an antibody target. Whether an autoantibody or antibody against ARMH1 could matter depends on whether native ARMH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARMH1 is annotated at the cell surface, where native ARMH1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARMH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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