Seroatlas · Human Serome Atlas

ARMCX4

Armadillo repeat-containing X-linked protein 4

Also known as: ARMX4_HUMAN, CXorf35, GASP4, MGC40053

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5H9R4
Gene: ARMCX4
Ensembl: ENSG00000196440
Chromosome: X
Canonical length: 2290 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

The product of this gene belongs to the armadillo repeat-containing family of proteins, which interact with other proteins in a variety of cellular processes. The function of this family member is currently unknown. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

2290 residues, UniProt reviewed canonical sequence.

>Q5H9R4|ARMCX4
     1  MGRIQEVGWV TAGLVIWAGT CYYIYKFTKG RAQSVRTLAR NGSTVKMETV VGVQSQTLAI
    61  NEAEIKTKPQ VEIGAETGAR SGPRAEVETK ATAIAIHRAN SQAKAMVGAE PETQSESKVV
   121  AGTLVMTEAV TLTEVKAKAR EVAMKEAVTQ TDAEAGKIVK KEAVTQTKAK AWALVAKTEA
   181  KREAMTQTKA ETHILAEKET EINRVMVTQS ETLAVPREVA KMGATNKTGI VDETKTRALE
   241  ETVSVAKTQS EARPGATVDA RGNPNGMSRE VAGVDMKSCA QSQAVTKIQG DDMPGTGVED
   301  MGNCKTMSRA ESGADTRASA QPQIFAKTQT EAIPGAKIDA GGNTNAMCKV GAGADVRACI
   361  QPQTVAKKQA EVTSGARVDG RGNTNVISKA ITGADMRAAA QPQAVASTHA EAMSDAKVKN
   421  RGNPNAMTKA GAKANLRANS QVEALPDARD KSRGNPNVMA KVGDGTDMLS CTQPQLVASV
   481  QADTLSDGKI KVRGNVNTMP KEGAGVDMKA QGMAQSQGEA LPNTRGKARG KAKAKCKTGP
   541  GMDMKTCTQP QAGVKTPAEA LLDSRVDGRG NPNATSKAGT KADQRVCGQP LVVANPQGEA
   601  LPGAKNKVKG NPHTVLKVGA GEGTTDSAQP EAVVSFQGEA LLGTKNKVKG NPNVVLKAEV
   661  GEGAMGTAQL QIMASSKGEA LLDSKNKVKG NSNAVSKAGA GTDTTGSVQP QIVANSQGEV
   721  LPGAKNKIRG NPTTVPNSGV GPYTTDSARL QAVANSQGEV LPGAKNKVKA NLNAVSKAEA
   781  GMGATGSVQP QAVANSHCET LPGAKNKVRG NWNAVSKAGA GMDTRGSAQP QAVANSQGEV
   841  LPGAKNKVKG NPNVVSKAGA REDTVGSTQP QVLASSQRET LPGARNKVKG NSNVVSKAGA
   901  REDTMGSAQP QVVANSQRET LPGARNKVKG NSNAISKAEA GAGIMGSVQV QVVASFQGEV
   961  LPGAKNKVRG NSNAVPKAEA GADTVGSAQP QAVANSQSET LLGARNKVKG NTIAVPKAGT
  1021  GAGTRHSAQP QIVAGSQGET LPGARDKSMS TSEAEATAED EAYAKPEAEA MPTSESEGGS
  1081  GTQACRKTQP NIHDYYWNGI GVEDWIAAER WIKFRFQTMD GDWENSVSWA DDENEASIGS
  1141  WSGASDKAGI IRSWAVACDE TSVKSWAGAR AENVVGIGTW ARAGEQASGG LWAGGQTSEG
  1201  TWAGDKASGG AWTGAENQAS GGSWALAGNQ AIGELWAAGQ ASDGSWPGGQ ASGVSWVGEE
  1261  AIGGSWTGAE NQASEGSWAG AGAGNMSSVS YWAGVVDQAG GGSWAGTSDQ SGGGSKPRFE
  1321  DQASGEGSWA GAGGQASGGS MLGPEDQSSG RSWADTADQA SGGSRLGHVD QSSGGAWAGT
  1381  LDQSGGGSKP RFENQTTEEG SWAGAGGQAG GGSKVGPEDQ SSGRSWANSG DQISGGFLVG
  1441  IVDQANGGSW TGAGHPASVG PKPIFEDQVS GRGSWADARE QVVGDSRLGL RDQSSGDSWA
  1501  GTGDQASGWF CVCPGSQTNG GSWGGASGQD VGGSRPGPTN QSSAGSWDSP GSQVSGSCWT
  1561  GAGAVDQAGG CSKPGFEDQA IGGGFWPGAG DQTGGGSRPG SEDQSSGIGS WGVAGGQVLG
  1621  GARPGPADQS SGGSWAGTGN QSSGRSWIGP GDQAVDCSKP EFEDQACGGG SWAGAGSQAS
  1681  GESWAGSRPG NEAIGGSRMG SEDQATGGSW ARSEDQASGR FQVSFEVEAN EGFWFGPGAE
  1741  AVIGSWCWTE EKADIVSRPD DKDEATTASR SGAGEEAMIC SRIEAENKAS SGSWIRSEEV
  1801  AYMGSCVGAE AGAGAEAGAG AEAGAGAGAE AGAEAGAGAG AGPGTESGAG IWSWDGDATT
  1861  VESRLGAGEE AGVESWTLAR NVGEDELSRE SSPDIEEISL RSLFWAESEN SNTFRSKSGK
  1921  DASFESGAGD NTSIKDKFEA AGGVDIGSWF CAGNENTSED KSAPKAKAKK SSESRGIYPY
  1981  MVPGAGMGSW DGAMIWSETK FAHQSEASFP VEDESRKQTR TGEKTRPWSC RCKHEANMDP
  2041  RDLEKLICMI EMTEDPSVHE IANNALYNSA DYSYSHEVVR NVGGISVIES LLNNPYPSVR
  2101  QKALNALNNI SVAAENHRKV KTYLNQVCED TVTYPLNSNV QLAGLRLIRH LTITSEYQHM
  2161  VTNYISEFLR LLTVGSGETK DHVLGMLLNF SKNPSMTKDL LIANAPTSLI NIFSKKETKE
  2221  NILNALSLFE NINYHFKRRA KAFTQDKFSK NSLYFLFQRP KACAKKLRAL AAECNDPEVK
  2281  ERVELLISKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARMCX4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 6 nTPM

Expression across tissuesHPA

Tissue

ovary: 6 nTPM
cerebral cortex: 4.5 nTPM
seminal vesicle: 4.4 nTPM
parathyroid gland: 4.3 nTPM
pituitary gland: 4.2 nTPM
adrenal gland: 3.7 nTPM

Single-cell type

sertoli cells: 237 nCPM
fibro-adipogenic progenitors: 199 nCPM
myonuclei: 167 nCPM
pituicytes/fscs: 164 nCPM
podocytes: 159 nCPM
lactotrophs: 153 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 8.6 nTPM
white matter: 6.9 nTPM
midbrain: 6.6 nTPM
pons: 6.5 nTPM
basal ganglia: 6.4 nTPM
cerebral cortex: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.12
gnomAD pLI: 1
gnomAD missense Z: 2.64
DepMap mean gene effect: 0.28
DepMap dependency class: none

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARMCX4 as an antibody target. Whether an autoantibody or antibody against ARMCX4 could matter depends on whether native ARMCX4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARMCX4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARMCX4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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