Seroatlas · Human Serome Atlas

ARMCX2

Armadillo repeat-containing X-linked protein 2

Also known as: ALEX2, ARMX2_HUMAN, GASP9, KIAA0512

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L311
Gene: ARMCX2
Ensembl: ENSG00000184867
Chromosome: X
Canonical length: 632 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

This gene encodes a protein containing a potential N-terminal transmembrane domain and multiple armadillo (arm) repeats. Proteins containing arm repeats are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is located in a cluster of related genes on chromosome X. There is a pseudogene for this gene on chromosome 7. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

632 residues, UniProt reviewed canonical sequence.

>Q7L311|ARMCX2
     1  MSRVRDAGCV AAGIVIGAGA WYCVYKYTRG RDQTKKRMAK PKNRAVAGTG ARARAGLRAG
    61  FTIDLGSGFS PPTPVRAEAE DRAQDEASAL DTVGAEAVAP AASSAEAQSG AGSQAQEADG
   121  AGVGPKAESV VGAAMASAIA PPPGVTEALG AAEAPAMAGA PKVAEAPREA ETSRAAVPPG
   181  TVVPTEAAAP TEVTEGPGVA APTKVAEAPG VASPTEAAEA PVPATPTGAA APTGAAESPG
   241  TSGSPRTAVV PGTSAAKKAT PGAHTGAIPK ATSATGAVPK GGGKGVTRSR NGGKGKGKKS
   301  KVEVDELGMG FRPGDGAAAA AAASANGGQA FLAEVPDSEE GESGWTDTES DSDSEPETQR
   361  RGRGRRPVAM QKRPFPYEID EILGVRDLRK VLALLQKSDD PFIQQVALLT LSNNANYSCN
   421  QETIRKLGGL PIIANMINKT DPHIKEKALM AMNNLSENYE NQGRLQVYMN KVMDDIMASN
   481  LNSAVQVVGL KFLTNMTITN DYQHLLVNSI ANFFRLLSQG GGKIKVEILK ILSNFAENPD
   541  MLKKLLSTQV PASFSSLYNS YVESEILINA LTLFEIIYDN LRAEVFNYRE FNKGSLFYLC
   601  TTSGVCVKKI RALANHHDLL VKVKVIKLVN KF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARMCX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 146 nTPM

Expression across tissuesHPA

Tissue

epididymis: 146 nTPM
pituitary gland: 70 nTPM
parathyroid gland: 67 nTPM
seminal vesicle: 64 nTPM
thyroid gland: 56 nTPM
adrenal gland: 42 nTPM

Single-cell type

epididymal principal cells: 145 nCPM
epididymal clear cells: 74 nCPM
epididymal basal cells: 65 nCPM
somatotrophs: 57 nCPM
epididymal efferent duct absorptive cells: 55 nCPM
decidual stromal cells: 45 nCPM

Immune cell

naive B-cell: 4 nTPM
memory B-cell: 2.9 nTPM
NK-cell: 2.8 nTPM
naive CD8 T-cell: 2.6 nTPM
naive CD4 T-cell: 2.5 nTPM
total PBMC: 1.1 nTPM

Brain region

hypothalamus: 41 nTPM
cerebral cortex: 36 nTPM
basal ganglia: 34 nTPM
pons: 32 nTPM
choroid plexus: 30 nTPM
hippocampal formation: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.69
gnomAD missense Z: 1.51
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARMCX2 as an antibody target. Whether an autoantibody or antibody against ARMCX2 could matter depends on whether native ARMCX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARMCX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARMCX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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