Seroatlas · Human Serome Atlas

ARMC6

Armadillo repeat-containing protein 6

Also known as: ARMC6_HUMAN, MGC19595

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NXE6
Gene: ARMC6
Ensembl: ENSG00000105676
Chromosome: 19
Canonical length: 501 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The function of this gene's protein product has not been determined. A related protein in mouse suggests that this protein has a conserved function. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

501 residues, UniProt reviewed canonical sequence.

>Q6NXE6|ARMC6
     1  MSERCCSRYS SGASIGCTPT STQAKMVSKR IAQETFDAAV RENIEEFAMG PEEAVKEAVE
    61  QFESQGVDLS NIVKTAPKVS ADGSQEPTHD ILQMLSDLQE SVASSRPQEV SAYLTRFCDQ
   121  CKQDKACRFL AAQKGAYPII FTAWKLATAG DQGLLLQSLN ALSVLTDGQP DLLDAQGLQL
   181  LVATLTQNAD EADLTCSGIR CVRHACLKHE QNRQDLVKAG VLPLLTGAIT HHGHHTDVVR
   241  EACWALRVMT FDDDIRVPFG HAHNHAKMIV QENKGLKVLI EATKAFLDNP GILSELCGTL
   301  SRLAIRNEFC QEVVDLGGLS ILVSLLADCN DHQMRDQSGV QELVKQVLST LRAIAGNDDV
   361  KDAIVRAGGT ESIVAAMTQH LTSPQVCEQS CAALCFLALR KPDNSRIIVE GGGAVAALQA
   421  MKAHPQKAGV QKQACMLIRN LVAHGQAFSK PILDLGAEAL IMQARSAHRD CEDVAKAALR
   481  DLGCHVELRE LWTGQRGNLA P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARMC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 112 nTPM

Expression across tissuesHPA

Tissue

liver: 112 nTPM
testis: 23 nTPM
thymus: 22 nTPM
skeletal muscle: 20 nTPM
cerebellum: 20 nTPM
cerebral cortex: 20 nTPM

Single-cell type

late spermatids: 89 nCPM
hepatocytes: 67 nCPM
erythrocyte progenitors: 56 nCPM
megakaryocytes: 43 nCPM
late primary spermatocytes: 41 nCPM
differentiating spermatogonia: 35 nCPM

Immune cell

NK-cell: 31 nTPM
myeloid DC: 28 nTPM
T-reg: 24 nTPM
gdT-cell: 22 nTPM
intermediate monocyte: 20 nTPM
memory CD8 T-cell: 19 nTPM

Brain region

pons: 28 nTPM
medulla oblongata: 28 nTPM
hypothalamus: 26 nTPM
cerebral cortex: 26 nTPM
midbrain: 25 nTPM
cerebellum: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

hematopoietic progenitor cell differentiation

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARMC6 as an antibody target. Whether an autoantibody or antibody against ARMC6 could matter depends on whether native ARMC6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARMC6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARMC6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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