Seroatlas · Human Serome Atlas

ARMC2

Armadillo repeat-containing protein 2

Also known as: ARMC2_HUMAN, bA787I22.1, DKFZp434P0714

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NEN0
Gene: ARMC2
Ensembl: ENSG00000118690
Chromosome: 6
Canonical length: 867 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

Involved in sperm axoneme assembly. Implicated in spermatogenic failure 38. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

867 residues, UniProt reviewed canonical sequence.

>Q8NEN0|ARMC2
     1  MLSPNDKMLG KLDPFYQPSV SKQKTSAEII SEARNALRTV RTQRPFTPQE AQRKLFGPAS
    61  SRTSENRPPS SFSLHASSFE SSDSRPISGT RLSPLELKPK VPASPTREED SCFSFPKPPV
   121  DPAKIRRVSN ARARLFRAAS QRALLPDRSL PPSDSKKTVE SKETVMMGDS MVKINGIYLT
   181  KSNAICHLKS HPLQLTDDGG FSEIKEQEMF KGTTSLPSHL KNGGDQGKRH ARASSCPSSS
   241  DLSRLQTKAV PKADLQEEDA EIEVDEVFWN TRIVPILREL EKEENIETVC AACTQLHHAL
   301  EEGNMLGNKF KGRSILLKTL CKLVDVGSDS LSLKLAKIIL ALKVSRKNLL NVCKLIFKIS
   361  RNEKNDSLIQ NDSILESLLE VLRSEDLQTN MEAFLYCMGS IKFISGNLGF LNEMISKGAV
   421  EILINLIKQI NENIKKCGTF LPNSGHLLVQ VTATLRNLVD SSLVRSKFLN ISALPQLCTA
   481  MEQYKGDKDV CTNIARIFSK LTSYRDCCTA LASYSRCYAL FLNLINKYQK KQDLVVRVVF
   541  ILGNLTAKNN QAREQFSKEK GSIQTLLSLF QTFHQLDLHS QKPVGQRGEQ HRAQRPPSEA
   601  EDVLIKLTRV LANIAIHPGV GPVLAANPGI VGLLLTTLEY KSLDDCEELV INATATINNL
   661  SYYQVKNSII QDKKLYIAEL LLKLLVSNNM DGILEAVRVF GNLSQDHDVC DFIVQNNVHR
   721  FMMALLDAQH QDICFSACGV LLNLTVDKDK RVILKEGGGI KKLVDCLRDL GPTDWQLACL
   781  VCKTLWNFSE NITNASSCFG NEDTNTLLLL LSSFLDEELA LDGSFDPDLK NYHKLHWETE
   841  FKPVAQQLLN RIQRHHTFLE PLPIPSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARMC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

testis: 31 nTPM
retina: 25 nTPM
fallopian tube: 19 nTPM
choroid plexus: 13 nTPM
thyroid gland: 10 nTPM
parathyroid gland: 8.8 nTPM

Single-cell type

choroid plexus epithelial cells: 640 nCPM
ependymal cells: 574 nCPM
respiratory ciliated cells: 515 nCPM
fallopian tube ciliated cells: 257 nCPM
late spermatids: 223 nCPM
epididymal efferent duct ciliated cells: 180 nCPM

Immune cell

neutrophil: 6 nTPM
T-reg: 4.7 nTPM
basophil: 3.8 nTPM
intermediate monocyte: 3 nTPM
NK-cell: 2.9 nTPM
plasmacytoid DC: 2.8 nTPM

Brain region

choroid plexus: 106 nTPM
thalamus: 55 nTPM
basal ganglia: 55 nTPM
midbrain: 52 nTPM
cerebral cortex: 52 nTPM
amygdala: 46 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARMC2.

Disease | AllUniProt

Conditions ARMC2 is implicated in, by any mechanism.

Spermatogenic failure 38 (SPGF38) MIM:618433

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 157 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spermatogenic failure 38
Male infertility with teratozoospermia due to single gene mutation
Abnormal sperm tail morphology
Reduced sperm motility
Abnormal sperm morphology

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: 0.74
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

Armadillo
Armadillo-like helical
Armadillo-type fold
Armadillo repeat-containing protein 2

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARMC2 as an antibody target. Whether an autoantibody or antibody against ARMC2 could matter depends on whether native ARMC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARMC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARMC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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