ARLN
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN
Also known as: ALN, C4orf3, HCVFTP1, SRALN_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WVX3
- Gene
- ARLN
- Ensembl
- ENSG00000164096
- Chromosome
- 4
- Canonical length
- 66 aa
- Protein class
- Predicted membrane proteins, Transporters
- Subcellular location
- Endoplasmic reticulum
- Quaternary structure
- Homooligomer
OverviewNCBI Gene
Predicted to act upstream of or within negative regulation of ATPase-coupled calcium transmembrane transporter activity. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
66 residues, UniProt reviewed canonical sequence.
>Q8WVX3|ARLN
1 MEVDAPGVDG RDGLRERRGF SEGGRQNFDV RPQSGANGLP KHSYWLDLWL FILFDVVVFL
61 FVYFLPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ARLN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 163 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 163 nTPM
- esophagus: 151 nTPM
- midbrain: 140 nTPM
- blood vessel: 114 nTPM
- vagina: 107 nTPM
- liver: 104 nTPM
Single-cell type
- esophageal apical cells: 17,731 nCPM
- esophageal suprabasal cells: 1,859 nCPM
- neutrophils: 769 nCPM
- syncytiotrophoblasts: 561 nCPM
- hepatocytes: 521 nCPM
- ocular epithelial cells: 510 nCPM
Immune cell
- basophil: 258 nTPM
- neutrophil: 240 nTPM
- total PBMC: 157 nTPM
- eosinophil: 146 nTPM
- intermediate monocyte: 133 nTPM
- plasmacytoid DC: 132 nTPM
Brain region
- white matter: 109 nTPM
- spinal cord: 108 nTPM
- thalamus: 108 nTPM
- medulla oblongata: 102 nTPM
- pons: 100 nTPM
- basal ganglia: 99 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.76
- gnomAD pLI
- 0.31
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Another-regulin
- Another-regulin-like
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ARLN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ARLN as an antibody target. Whether an autoantibody or antibody against ARLN could matter depends on whether native ARLN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ARLN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ARLN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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