Seroatlas · Human Serome Atlas

ARL14EPL

ARL14 effector protein-like

Also known as: A14EL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DKL9
Gene
ARL14EPL
Ensembl
ENSG00000268223
Chromosome
5
Canonical length
152 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ARL14EPL in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

152 residues, UniProt reviewed canonical sequence.

>P0DKL9|ARL14EPL
     1  MNEQSEKNNS IQERHTDHSF PEKNCQIGQK QLQQIERQLK CLAFRNPGPQ VADFNPETRQ
    61  QKKKARMSKM NEYFSTKYKI MRKYDKSGRL ICNDADLCDC LEKNCLGCFY PCPKCNSNKC
   121  GPECRCNRRW VYDAIVTESG EVISTLPFNV PD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARL14EPL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
0.3 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 0.3 nTPM
  • appendix: 0.2 nTPM
  • lung: 0.2 nTPM
  • lymph node: 0.2 nTPM
  • testis: 0.2 nTPM
  • tonsil: 0.2 nTPM

Single-cell type

  • parietal cells: 7.1 nCPM
  • early spermatids: 5.5 nCPM
  • gastric chief cells: 5.5 nCPM
  • cardiomyocytes: 4.4 nCPM
  • mucous neck cells: 3.5 nCPM
  • endometrial ciliated cells: 3.2 nCPM

Immune cell

  • MAIT T-cell: 0.5 nTPM
  • intermediate monocyte: 0.4 nTPM
  • non-classical monocyte: 0.3 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • medulla oblongata: 0.3 nTPM
  • hypothalamus: 0.1 nTPM
  • midbrain: 0.1 nTPM
  • pons: 0.1 nTPM
  • thalamus: 0.1 nTPM
  • white matter: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.23
gnomAD pLI
0.03
gnomAD missense Z
-0.19
DepMap mean gene effect
0.04
DepMap dependency class
none

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARL14EPL as an antibody target. Whether an autoantibody or antibody against ARL14EPL could matter depends on whether native ARL14EPL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARL14EPL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARL14EPL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARL14EPL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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