Seroatlas · Human Serome Atlas

ARK2C

E3 ubiquitin-protein ligase ARK2C

Also known as: ARK2C_HUMAN, ARKL2, lncAMPC, RNF111L2, RNF165

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZSG1
Gene: ARK2C
Ensembl: ENSG00000141622
Chromosome: 18
Canonical length: 346 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in motor neuron axon guidance and positive regulation of BMP signaling pathway. Predicted to act upstream of or within several processes, including forelimb morphogenesis; nervous system development; and protein polyubiquitination. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>Q6ZSG1|ARK2C
     1  MVLVHVGYLV LPVFGSVRNR GAPFQRSQHP HATSCRHFHL GPPQPQQLAP DFPLAHPVQS
    61  QPGLSAHMAP AHQHSGALHQ SLTPLPTLQF QDVTGPSFLP QALHQQYLLQ QQLLEAQHRR
   121  LVSHPRRSQE RVSVHPHRLH PSFDFGQLQT PQPRYLAEGT DWDLSVDAGL SPAQFQVRPI
   181  PQHYQHYLAT PRMHHFPRNS SSTQMVVHEI RNYPYPQLHF LALQGLNPSR HTSAVRESYE
   241  ELLQLEDRLG NVTRGAVQNT IERFTFPHKY KKRRPQDGKG KKDEGEESDT DEKCTICLSM
   301  LEDGEDVRRL PCMHLFHQLC VDQWLAMSKK CPICRVDIET QLGADS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARK2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 22 nTPM
retina: 17 nTPM
cerebral cortex: 5.1 nTPM
liver: 4.7 nTPM
pituitary gland: 3.7 nTPM
thyroid gland: 3.7 nTPM

Single-cell type

retinal amacrine cells: 178 nCPM
retinal horizontal cells: 122 nCPM
cone photoreceptor cells: 93 nCPM
lactotrophs: 84 nCPM
brain excitatory neurons: 79 nCPM
ependymal cells: 76 nCPM

Immune cell

NK-cell: 1.1 nTPM
plasmacytoid DC: 0.4 nTPM
MAIT T-cell: 0.3 nTPM
eosinophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 32 nTPM
cerebral cortex: 29 nTPM
hippocampal formation: 26 nTPM
amygdala: 22 nTPM
basal ganglia: 21 nTPM
white matter: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARK2C as an antibody target. Whether an autoantibody or antibody against ARK2C could matter depends on whether native ARK2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARK2C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARK2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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