Seroatlas · Human Serome Atlas

ARIH2OS

Uncharacterized protein ARIH2OS

Also known as: ARI2O_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7S6
Gene: ARIH2OS
Canonical length: 290 aa

OverviewNCBI Gene

No narrative summary is available for ARIH2OS in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

290 residues, UniProt reviewed canonical sequence.

>Q8N7S6|ARIH2OS
     1  MLGQRAGDGE RPGLPGDGEG GVPARPGRRA ERPPQRPAKV NKAVTCAAHL PGAAASRPLS
    61  PNKPDRVRPG QRDRIGAKRQ RRRRADAGQA RAASSRRVVP TAPEVLGAVA SLPDRGRPTV
   121  ARVATGSRLE GLFSAASLKL SALTQSLTRV RQAPTASGAT IRLPASPVEM FLTSAFLTGF
   181  SFHCLYSGIG HGEDILASVE QITIVSRPLS GQRGAGPGNS AYTPRRSQGG PRAATTPGFR
   241  FPCRGLVRRA VLRLTVTVQD CILTALLAVS FHSIGVVIMT SSYLLGPVVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARIH2OS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.66

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.81

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARIH2OS as an antibody target. Whether an autoantibody or antibody against ARIH2OS could matter depends on whether native ARIH2OS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARIH2OS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARIH2OS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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