ARID3B

Protein identityUniProt · HPA

UniProt accession

Q8IVW6

Gene

ARID3B

Ensembl

ENSG00000179361

Chromosome

15

Canonical length

561 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

561 residues, UniProt reviewed canonical sequence.

>Q8IVW6|ARID3B
     1  MEPLQQQQQQ QQQQQKQPHL APLQMDAREK QGQQMREAQF LYAQKLVTQP TLLSATAGRP
    61  SGSTPLGPLA RVPPTAAVAQ VFERGNMNSE PEEEDGGLED EDGDDEVAEV AEKETQAASK
   121  YFHVQKVARQ DPRVAPMSNL LPAPGLPPHG QQAKEDHTKD ASKASPSVST AGQPNWNLDE
   181  QLKQNGGLAW SDDADGGRGR EISRDFAKLY ELDGDPERKE FLDDLFVFMQ KRGTPINRIP
   241  IMAKQILDLY MLYKLVTEKG GLVEIINKKI WREITKGLNL PTSITSAAFT LRTQYMKYLY
   301  AYECEKKALS SPAELQAAID GNRREGRRPS YSSSLFGYSP AAATAAAAAG APALLSPPKI
   361  RFPILGLGSS SGTNTSSPRI SPATTLRKGD GAPVTTVPVP NRLAVPVTLA SQQAGTRTAA
   421  LEQLRERLES GEPAEKKASR LSEEEQRLVQ QAFQRNFFSM ARQLPMKIRI NGRAEDRAEA
   481  SAAALNLTTS SIGSINMSVD IDGTTYAGVL FAQKPVVHLI TGSAPQSLGS SASSSSSSHC
   541  SPSPTSSRGT PSAEPSTSWS L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARID3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.6

Highest tissue expression

23 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.47

gnomAD pLI

0.38

gnomAD missense Z

1.27

DepMap mean gene effect

-0.12

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• positive regulation of transcription by RNA polymerase II
• regulation of transcription by RNA polymerase II

Molecular functions

• DNA binding

Cellular components

• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• ARID DNA-binding domain
• REKLES domain
• ARID DNA-binding domain superfamily
• AT-rich interactive domain-containing protein 3
• ARID/BRIGHT DNA binding domain

KeywordsUniProt

• Acetylation
• DNA-binding
• Methylation
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation
• Tumor suppressor

InteractionsUniProt · HPA

Protein binding partners of ARID3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RB1