Seroatlas · Human Serome Atlas

ARHGEF35

Rho guanine nucleotide exchange factor 35

Also known as: ARG35_HUMAN, ARHGEF5L, CTAGE4, FLJ43692

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A5YM69
Gene: ARHGEF35
Ensembl: ENSG00000213214
Chromosome: 7
Canonical length: 484 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ARHGEF35 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

484 residues, UniProt reviewed canonical sequence.

>A5YM69|ARHGEF35
     1  MEAEEAQHGA SPPISAIEEF SIIPEAPMRS SQVSALGLEA QEDEDPSYKW REEHRLSATQ
    61  QSELRDVCDY AIETMPSFPK EGSADVEPNQ ESLVAEACDT PEHWEAVPQS LAGRQARTLA
   121  PPELWACPIQ SEHLDMAPFS SDLGSEEEEV EFWPGLTSLT LGSGQAEEEE ETSSDNSGQT
   181  RYYSPCEEHP AETNQNEGAE SGTIRQGEEL PSEELQESQG LLHPQEVQVL EEQGQQEAGF
   241  RGEGTLREDV CADGLLGEEQ MIEQVNDEKG EQKQKQEQVQ DVMLGRQGER MGLTGEPEGL
   301  NDGEWEQEDM ERKAQGQGGP EQGEERKREL QVPEENRADS QDEKSQTFLG KSEEVTGKQE
   361  DHGIKEKGVP VSGQEAKEPE SWDGGRLGAV GRARSREEEN EHHGPSMPAL IAPEDSPHCD
   421  LFPGASYLVT QIPGTQTESR AEELSPAALS PLLEPIRCSH QPISLLGSFL TEESPDKEKL
   481  LSVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGEF35 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.73
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 20 nTPM
skin: 15 nTPM
breast: 14 nTPM
rectum: 14 nTPM
duodenum: 12 nTPM
esophagus: 11 nTPM

Single-cell type

endometrial luminal cells: 6.5 nCPM
basal keratinocytes: 5.7 nCPM
suprabasal keratinocytes: 5.6 nCPM
gastric chief cells: 4.4 nCPM
endometrial ciliated cells: 4.1 nCPM
loop of henle epithelial cells: 3.8 nCPM

Immune cell

T-reg: 0.8 nTPM
memory CD4 T-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

choroid plexus: 6.3 nTPM
midbrain: 2.1 nTPM
medulla oblongata: 2 nTPM
pons: 1.9 nTPM
thalamus: 1.8 nTPM
spinal cord: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.68
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of ARHGEF35 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GRB2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGEF35 as an antibody target. Whether an autoantibody or antibody against ARHGEF35 could matter depends on whether native ARHGEF35 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGEF35 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGEF35 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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