Seroatlas · Human Serome Atlas

ARHGDIG

Rho GDP-dissociation inhibitor 3

Also known as: GDIR3_HUMAN, RHOGDI-3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99819
Gene: ARHGDIG
Ensembl: ENSG00000242173
Chromosome: 16
Canonical length: 225 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

225 residues, UniProt reviewed canonical sequence.

>Q99819|ARHGDIG
     1  MLGLDACELG AQLLELLRLA LCARVLLADK EGGPPAVDEV LDEAVPEYRA PGRKSLLEIR
    61  QLDPDDRSLA KYKRVLLGPL PPAVDPSLPN VQVTRLTLLS EQAPGPVVMD LTGDLAVLKD
   121  QVFVLKEGVD YRVKISFKVH REIVSGLKCL HHTYRRGLRV DKTVYMVGSY GPSAQEYEFV
   181  TPVEEAPRGA LVRGPYLVVS LFTDDDRTHH LSWEWGLCIC QDWKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGDIG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 246 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 246 nTPM
cerebellum: 202 nTPM
amygdala: 189 nTPM
hippocampal formation: 142 nTPM
hypothalamus: 128 nTPM
pancreas: 106 nTPM

Single-cell type

other brain neurons: 92 nCPM
pancreatic acinar cells: 83 nCPM
gastric chief cells: 52 nCPM
brain excitatory neurons: 49 nCPM
enterocytes: 48 nCPM
brain inhibitory neurons: 43 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 217 nTPM
white matter: 179 nTPM
basal ganglia: 175 nTPM
hypothalamus: 157 nTPM
cerebellum: 148 nTPM
amygdala: 141 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.92
gnomAD missense Z: 0
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGDIG as an antibody target. Whether an autoantibody or antibody against ARHGDIG could matter depends on whether native ARHGDIG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGDIG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGDIG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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