Seroatlas · Human Serome Atlas

ARHGAP6

Rho GTPase-activating protein 6

Also known as: RHG06_HUMAN, rhoGAPX-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43182
Gene
ARHGAP6
Ensembl
ENSG00000047648
Chromosome
X
Canonical length
974 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Mitotic spindle,Cytosol

OverviewNCBI Gene

This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

974 residues, UniProt reviewed canonical sequence.

>O43182|ARHGAP6
     1  MSAQSLLHSV FSCSSPASSS AASAKGFSKR KLRQTRSLDP ALIGGCGSDE AGAEGSARGA
    61  TAGRLYSPSL PAESLGPRLA SSSRGPPPRA TRLPPPGPLC SSFSTPSTPQ EKSPSGSFHF
   121  DYEVPLGRGG LKKSMAWDLP SVLAGPASSR SASSILCSSG GGPNGIFASP RRWLQQRKFQ
   181  SPPDSRGHPY VVWKSEGDFT WNSMSGRSVR LRSVPIQSLS ELERARLQEV AFYQLQQDCD
   241  LSCQITIPKD GQKRKKSLRK KLDSLGKEKN KDKEFIPQAF GMPLSQVIAN DRAYKLKQDL
   301  QRDEQKDASD FVASLLPFGN KRQNKELSSS NSSLSSTSET PNESTSPNTP EPAPRARRRG
   361  AMSVDSITDL DDNQSRLLEA LQLSLPAEAQ SKKEKARDKK LSLNPIYRQV PRLVDSCCQH
   421  LEKHGLQTVG IFRVGSSKKR VRQLREEFDR GIDVSLEEEH SVHDVAALLK EFLRDMPDPL
   481  LTRELYTAFI NTLLLEPEEQ LGTLQLLIYL LPPCNCDTLH RLLQFLSIVA RHADDNISKD
   541  GQEVTGNKMT SLNLATIFGP NLLHKQKSSD KEFSVQSSAR AEESTAIIAV VQKMIENYEA
   601  LFMVPPDLQN EVLISLLETD PDVVDYLLRR KASQSSSPDM LQSEVSFSVG GRHSSTDSNK
   661  ASSGDISPYD NNSPVLSERS LLAMQEDAAP GGSEKLYRVP GQFMLVGHLS SSKSRESSPG
   721  PRLGKDLSEE PFDIWGTWHS TLKSGSKDPG MTGSSGDIFE SSSLRAGPCS LSQGNLSPNW
   781  PRWQGSPAEL DSDTQGARRT QAAAPATEGR AHPAVSRACS TPHVQVAGKA ERPTARSEQY
   841  LTLSGAHDLS ESELDVAGLQ SRATPQCQRP HGSGRDDKRP PPPYPGPGKP AAAAAWIQGP
   901  PEGVETPTDQ GGQAAEREQQ VTQKKLSSAN SLPAGEQDSP RLGDAGWLDW QRERWQIWEL
   961  LSTDNPDALP ETLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • seminal vesicle: 29 nTPM
  • prostate: 26 nTPM
  • thyroid gland: 24 nTPM
  • ovary: 18 nTPM
  • colon: 13 nTPM
  • smooth muscle: 12 nTPM

Single-cell type

  • distal convoluted tubule cells: 2,375 nCPM
  • prostatic glandular cells: 1,520 nCPM
  • loop of henle epithelial cells: 985 nCPM
  • renal connecting tubule cells: 876 nCPM
  • proximal tubule cells: 789 nCPM
  • mesothelial cells: 738 nCPM

Immune cell

  • total PBMC: 0.5 nTPM
  • basophil: 0.2 nTPM
  • memory B-cell: 0.2 nTPM
  • neutrophil: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • intermediate monocyte: 0.1 nTPM

Brain region

  • amygdala: 18 nTPM
  • hypothalamus: 12 nTPM
  • basal ganglia: 10 nTPM
  • hippocampal formation: 10 nTPM
  • cerebral cortex: 8.6 nTPM
  • midbrain: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
1
gnomAD missense Z
1.82
DepMap mean gene effect
0.16
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGAP6 as an antibody target. Whether an autoantibody or antibody against ARHGAP6 could matter depends on whether native ARHGAP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGAP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGAP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARHGAP6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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