Seroatlas · Human Serome Atlas

ARHGAP40

Rho GTPase-activating protein 40

Also known as: C20orf95, dJ1100H13.4, RHG40_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TG30
Gene: ARHGAP40
Ensembl: ENSG00000124143
Chromosome: 20
Canonical length: 675 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Centrosome,Cytosol

OverviewNCBI Gene

Predicted to enable GTPase activator activity. Predicted to be involved in regulation of actin filament polymerization and regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

675 residues, UniProt reviewed canonical sequence.

>Q5TG30|ARHGAP40
     1  MAEPALLPAA QMERLAPGPL ASPCPRIPRA RIARRCAQRW ADLGCSSGPS SGRMDQLPQK
    61  NLLRLHPAGS AGCSTGVESS SMDGFWMEVE QIQQRDELRE EDSGGNEGQL PEEGEAESQW
   121  LQDTGLSGLL GGLGLDGDHQ ELLSTLTQTQ VAAVCRRLDI YARSVRRQHK TPVRDVRDVF
   181  GVFNSGKMSS ENGDSGMKGA QLSSGASKFP PAAEPGGLQE QAGREEAFNM DSAYSEQAAV
   241  LLQRSRPSRG GTSAWGKCSL PKFTVPKGRL GVTRIGDLSL QDMRKVPSLA LIELTALCDI
   301  LGLDLKRSKA GKWKAAETRL FGVPLDSLLE ADHKVLPSTQ VPLVLQALLS CLEKRGLDME
   361  GILRVPGSQA RVKGLEQKLE RDFYAGLFSW DEVHHNDASD LLKRFIRKLP TPLLTAEYLP
   421  AFAVVPNIPN LKQRLQVLHL LILILPEPNR NALKALLEFL RKVVAREQHN KMTLRNVSTV
   481  MAPNLFLHQG RPPKLPKGKE KQLAEGAAEV VQIMVHYQDL LWTVASFLVA QVRKLNDSSS
   541  RRPQLCDAGL KTWLRRMHAD RDKAGDGLEA TPKVAKIQVV WPIKDPLKVP LTPSTKVAHV
   601  LRQFTEHLSP GSKGQEDSED MDSLLLHHRS MESANILLYE VGGNINEHRL DPDAYLLDLY
   661  RANPHGEWVL KQNPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP40 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

skin: 42 nTPM
epididymis: 34 nTPM
breast: 29 nTPM
esophagus: 25 nTPM
cervix: 7.4 nTPM
seminal vesicle: 7.4 nTPM

Single-cell type

esophageal apical cells: 116 nCPM
breast hormone-responsive cells: 38 nCPM
early spermatids: 21 nCPM
prostatic glandular cells: 17 nCPM
urothelial cells: 17 nCPM
epididymal principal cells: 16 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 3.6 nTPM
basal ganglia: 2.4 nTPM
medulla oblongata: 1.5 nTPM
pons: 1.4 nTPM
thalamus: 1.2 nTPM
cerebral cortex: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 1.53

OntologyGO

Biological processes

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

GTPase activation

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGAP40 as an antibody target. Whether an autoantibody or antibody against ARHGAP40 could matter depends on whether native ARHGAP40 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGAP40 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGAP40 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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