Seroatlas · Human Serome Atlas

ARHGAP39

Rho GTPase-activating protein 39

Also known as: CrGAP, KIAA1688, RHG39_HUMAN, Vilse

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C0H5
Gene: ARHGAP39
Ensembl: ENSG00000147799
Chromosome: 8
Canonical length: 1083 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable GTPase activator activity. Involved in postsynapse organization. Is active in glutamatergic synapse. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1083 residues, UniProt reviewed canonical sequence.

>Q9C0H5|ARHGAP39
     1  MSQTQDYECR SHNVDLPESR IPGSNTRLEW VEIIEPRTRE RMYANLVTGE CVWDPPAGVR
    61  IKRTSENQWW ELFDPNTSRF YYYNASTQRT VWHRPQGCDI IPLAKLQTLK QNTESPRASA
   121  ESSPGRGSSV SREGSTSSSL EPEPDTEKAQ ELPARAGRPA AFGTVKEDSG SSSPPGVFLE
   181  KDYEIYRDYS ADGQLLHYRT SSLRWNSGAK ERMLIKVADR EPSFLAAQGN GYAPDGPPGV
   241  RSRRPSGSQH SPSLQTFAPE ADGTIFFPER RPSPFLKRAE LPGSSSPLLA QPRKPSGDSQ
   301  PSSPRYGYEP PLYEEPPVEY QAPIYDEPPM DVQFEAGGGY QAGSPQRSPG RKPRPFLQPN
   361  KQGPPSPCQQ LVLTKQKCPE RFLSLEYSPA GKEYVRQLVY VEQAGSSPKL RAGPRHKYAP
   421  NPGGGSYSLQ PSPCLLRDQR LGVKSGDYST MEGPELRHSQ PPTPLPQAQE DAMSWSSQQD
   481  TLSSTGYSPG TRKRKSRKPS LCQATSATPT EGPGDLLVEQ PLAEEQPPCG TSLAPVKRAE
   541  GEAEGARGAA EPFLAQARLA WEAQQAHFHM KQRSSWDSQQ DGSGYESDGA LPLPMPGPVV
   601  RAFSEDEALA QQENRHWRRG TFEKLGFPQI LLEKSVSVQT NLASPEPYLH PSQSEDLAAC
   661  AQFESSRQSR SGVPSSSCVF PTFTLRKPSS ETDIENWASK HFNKHTQGLF RRKVSIANML
   721  AWSSESIKKP MIVTSDRHVK KEACELFKLI QMYMGDRRAK ADPLHVALEV ATKGWSVQGL
   781  RDELYIQLCR QTTENFRLES LARGWELMAI CLAFFPPTPK FHSYLEGYIY RHMDPVNDTK
   841  GVAISTYAKY CYHKLQKAAL TGAKKGLKKP NVEEIRHAKN AVFSPSMFGS ALQEVMGMQR
   901  ERYPERQLPW VQTRLSEEVL ALNGDQTEGI FRVPGDIDEV NALKLQVDQW KVPTGLEDPH
   961  VPASLLKLWY RELEEPLIPH EFYEQCIAHY DSPEAAVAVV HALPRINRMV LCYLIRFLQV
  1021  FVQPANVAVT KMDVSNLAMV MAPNCLRCQS DDPRVIFENT RKEMSFLRVL IQHLDTSFME
  1081  GVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

testis: 20 nTPM
spinal cord: 16 nTPM
cerebral cortex: 15 nTPM
cerebellum: 14 nTPM
hippocampal formation: 12 nTPM
hypothalamus: 9.6 nTPM

Single-cell type

respiratory ciliated cells: 135 nCPM
endometrial ciliated cells: 131 nCPM
ependymal cells: 107 nCPM
fallopian tube ciliated cells: 86 nCPM
schwann cells: 82 nCPM
epididymal efferent duct ciliated cells: 75 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 38 nTPM
white matter: 38 nTPM
medulla oblongata: 37 nTPM
hippocampal formation: 37 nTPM
midbrain: 32 nTPM
pons: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.01
gnomAD missense Z: 2.52
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGAP39 as an antibody target. Whether an autoantibody or antibody against ARHGAP39 could matter depends on whether native ARHGAP39 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGAP39 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGAP39 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...