Seroatlas · Human Serome Atlas

ARHGAP24

Rho GTPase-activating protein 24

Also known as: DKFZP564B1162, FilGAP, FLJ33877, RHG24_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N264
Gene: ARHGAP24
Ensembl: ENSG00000138639
Chromosome: 4
Canonical length: 748 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

748 residues, UniProt reviewed canonical sequence.

>Q8N264|ARHGAP24
     1  MEENNDSTEN PQQGQGRQNA IKCGWLRKQG GFVKTWHTRW FVLKGDQLYY FKDEDETKPL
    61  GTIFLPGNKV SEHPCNEENP GKFLFEVVPG GDRDRMTANH ESYLLMASTQ NDMEDWVKSI
   121  RRVIWGPFGG GIFGQKLEDT VRYEKRYGNR LAPMLVEQCV DFIRQRGLKE EGLFRLPGQA
   181  NLVKELQDAF DCGEKPSFDS NTDVHTVASL LKLYLRELPE PVIPYAKYED FLSCAKLLSK
   241  EEEAGVKELA KQVKSLPVVN YNLLKYICRF LDEVQSYSGV NKMSVQNLAT VFGPNILRPK
   301  VEDPLTIMEG TVVVQQLMSV MISKHDCLFP KDAELQSKPQ DGVSNNNEIQ KKATMGQLQN
   361  KENNNTKDSP SRQCSWDKSE SPQRSSMNNG SPTALSGSKT NSPKNSVHKL DVSRSPPLMV
   421  KKNPAFNKGS GIVTNGSFSS SNAEGLEKTQ TTPNGSLQAR RSSSLKVSGT KMGTHSVQNG
   481  TVRMGILNSD TLGNPTNVRN MSWLPNGYVT LRDNKQKEQA GELGQHNRLS TYDNVHQQFS
   541  MMNLDDKQSI DSATWSTSSC EISLPENSNS CRSSTTTCPE QDFFGGNFED PVLDGPPQDD
   601  LSHPRDYESK SDHRSVGGRS SRATSSSDNS ETFVGNSSSN HSALHSLVSS LKQEMTKQKI
   661  EYESRIKSLE QRNLTLETEM MSLHDELDQE RKKFTMIEIK MRNAERAKED AEKRNDMLQK
   721  EMEQFFSTFG ELTVEPRRTE RGNTIWIQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 93 nTPM

Expression across tissuesHPA

Tissue

kidney: 93 nTPM
pancreas: 28 nTPM
thyroid gland: 26 nTPM
heart muscle: 26 nTPM
stomach: 25 nTPM
placenta: 21 nTPM

Single-cell type

microglia: 4,378 nCPM
neutrophil progenitors: 1,961 nCPM
b-cells: 1,837 nCPM
neutrophils: 1,640 nCPM
syncytiotrophoblasts: 1,429 nCPM
fibro-adipogenic progenitors: 1,120 nCPM

Immune cell

memory B-cell: 47 nTPM
naive B-cell: 37 nTPM
classical monocyte: 16 nTPM
plasmacytoid DC: 13 nTPM
neutrophil: 5.5 nTPM
myeloid DC: 3.8 nTPM

Brain region

white matter: 48 nTPM
pons: 43 nTPM
spinal cord: 33 nTPM
midbrain: 32 nTPM
medulla oblongata: 31 nTPM
thalamus: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0
gnomAD missense Z: 0.15
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGAP24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FLNA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGAP24 as an antibody target. Whether an autoantibody or antibody against ARHGAP24 could matter depends on whether native ARHGAP24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGAP24 is annotated at the cell surface, where native ARHGAP24 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARHGAP24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...