Seroatlas · Human Serome Atlas

ARHGAP23

Rho GTPase-activating protein 23

Also known as: KIAA1501, RHG23_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P227
Gene
ARHGAP23
Ensembl
ENSG00000275832
Chromosome
17
Canonical length
1491 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

1491 residues, UniProt reviewed canonical sequence.

>Q9P227|ARHGAP23
     1  MNGVAFCLVG IPPRPEPRPP QLPLGPRDGC SPRRPFPWQG PRTLLLYKSP QDGFGFTLRH
    61  FIVYPPESAV HCSLKEEENG GRGGGPSPRY RLEPMDTIFV KNVKEDGPAH RAGLRTGDRL
   121  VKVNGESVIG KTYSQVIALI QNSDDTLELS IMPKDEDILQ LAYSQDAYLK GNEPYSGEAR
   181  SIPEPPPICY PRKTYAPPAR ASTRATMVPE PTSALPSDPR SPAAWSDPGL RVPPAARAHL
   241  DNSSLGMSQP RPSPGAFPHL SSEPRTPRAF PEPGSRVPPS RLECQQALSH WLSNQVPRRA
   301  GERRCPAMAP RARSASQDRL EEVAAPRPWP CSTSQDALSQ LGQEGWHRAR SDDYLSRATR
   361  SAEALGPGAL VSPRFERCGW ASQRSSARTP ACPTRDLPGP QAPPPSGLQG LDDLGYIGYR
   421  SYSPSFQRRT GLLHALSFRD SPFGGLPTFN LAQSPASFPP EASEPPRVVR PEPSTRALEP
   481  PAEDRGDEVV LRQKPPTGRK VQLTPARQMN LGFGDESPEP EASGRGERLG RKVAPLATTE
   541  DSLASIPFID EPTSPSIDLQ AKHVPASAVV SSAMNSAPVL GTSPSSPTFT FTLGRHYSQD
   601  CSSIKAGRRS SYLLAITTER SKSCDDGLNT FRDEGRVLRR LPNRIPSLRM LRSFFTDGSL
   661  DSWGTSEDAD APSKRHSTSD LSDATFSDIR REGWLYYKQI LTKKGKKAGS GLRQWKRVYA
   721  ALRARSLSLS KERREPGPAA AGAAAAGAGE DEAAPVCIGS CLVDISYSET KRRHVFRLTT
   781  ADFCEYLFQA EDRDDMLGWI RAIRENSRAE GEDPGCANQA LISKKLNDYR KVSHSSGPKA
   841  DSSPKGSRGL GGLKSEFLKQ SAARGLRTQD LPAGSKDDSA AAPKTPWGIN IIKKNKKAAP
   901  RAFGVRLEEC QPATENQRVP LIVAACCRIV EARGLESTGI YRVPGNNAVV SSLQEQLNRG
   961  PGDINLQDER WQDLNVISSL LKSFFRKLPE PLFTDDKYND FIEANRIEDA RERMRTLRKL
  1021  IRDLPGHYYE TLKFLVGHLK TIADHSEKNK MEPRNLALVF GPTLVRTSED NMTDMVTHMP
  1081  DRYKIVETLI QHSDWFFSDE EDKGERTPVG DKEPQAVPNI EYLLPNIGRT VPPGDPGSDS
  1141  TTCSSAKSKG SWAPKKEPYA REMLAISFIS AVNRKRKKRR EARGLGSSTD DDSEQEAHKP
  1201  GAGATAPGTQ ERPQGPLPGA VAPEAPGRLS PPAAPEERPA ADTRSIVSGY STLSTMDRSV
  1261  CSGASGRRAG AGDEADDERS ELSHVETDTE GAAGAGPGGR LTRRPSFSSH HLMPCDTLAR
  1321  RRLARGRPDG EGAGRGGPRA PEPPGSASSS SQESLRPPAA ALASRPSRME ALRLRLRGTA
  1381  DDMLAVRLRR PLSPETRRRR SSWRRHTVVV QSPLTDLNFN EWKELGGGGP PEPAGARAHS
  1441  DNKDSGLSSL ESTKARAPSS AASQPPAPGD TGSLQSQPPR RSAASRLHQC L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
82 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 82 nTPM
  • skin: 59 nTPM
  • esophagus: 59 nTPM
  • midbrain: 51 nTPM
  • hippocampal formation: 47 nTPM
  • cerebellum: 44 nTPM

Single-cell type

  • oligodendrocytes: 172 nCPM
  • podocytes: 88 nCPM
  • papillary tip epithelial cells: 79 nCPM
  • astrocytes: 41 nCPM
  • oligodendrocyte progenitor cells: 28 nCPM
  • bergmann glia: 26 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 201 nTPM
  • basal ganglia: 142 nTPM
  • cerebral cortex: 142 nTPM
  • thalamus: 142 nTPM
  • medulla oblongata: 140 nTPM
  • midbrain: 129 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
1
gnomAD missense Z
1.99
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGAP23 as an antibody target. Whether an autoantibody or antibody against ARHGAP23 could matter depends on whether native ARHGAP23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGAP23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGAP23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARHGAP23. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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