Seroatlas · Human Serome Atlas

ARHGAP15

Rho GTPase-activating protein 15

Also known as: BM046, RHG15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53QZ3
Gene: ARHGAP15
Ensembl: ENSG00000075884
Chromosome: 2
Canonical length: 475 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

475 residues, UniProt reviewed canonical sequence.

>Q53QZ3|ARHGAP15
     1  MQKSTNSDTS VETLNSTRQG TGAVQMRIKN ANSHHDRLSQ SKSMILTDVG KVTEPISRHR
    61  RNHSQHILKD VIPPLEQLMV EKEGYLQKAK IADGGKKLRK NWSTSWIVLS SRRIEFYKES
   121  KQQALSNMKT GHKPESVDLC GAHIEWAKEK SSRKNVFQIT TVSGNEFLLQ SDIDFIILDW
   181  FHAIKNAIDR LPKDSSCPSR NLELFKIQRS SSTELLSHYD SDIKEQKPEH RKSLMFRLHH
   241  SASDTSDKNR VKSRLKKFIT RRPSLKTLQE KGLIKDQIFG SHLHKVCERE NSTVPWFVKQ
   301  CIEAVEKRGL DVDGIYRVSG NLATIQKLRF IVNQEEKLNL DDSQWEDIHV VTGALKMFFR
   361  ELPEPLFPYS FFEQFVEAIK KQDNNTRIEA VKSLVQKLPP PNRDTMKVLF GHLTKIVAKA
   421  SKNLMSTQSL GIVFGPTLLR AENETGNMAI HMVYQNQIAE LMLSEYSKIF GSEED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 75 nTPM
thymus: 70 nTPM
lymph node: 55 nTPM
tonsil: 43 nTPM
spleen: 42 nTPM
appendix: 26 nTPM

Single-cell type

neutrophils: 10,528 nCPM
neutrophil progenitors: 5,135 nCPM
hematopoietic stem cells: 1,673 nCPM
b-cells: 1,669 nCPM
t-cells: 1,429 nCPM
monocyte progenitors: 1,334 nCPM

Immune cell

neutrophil: 208 nTPM
basophil: 182 nTPM
memory CD4 T-cell: 173 nTPM
MAIT T-cell: 162 nTPM
T-reg: 148 nTPM
eosinophil: 140 nTPM

Brain region

white matter: 18 nTPM
medulla oblongata: 15 nTPM
pons: 14 nTPM
thalamus: 13 nTPM
choroid plexus: 13 nTPM
hypothalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 0.14
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGAP15 as an antibody target. Whether an autoantibody or antibody against ARHGAP15 could matter depends on whether native ARHGAP15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGAP15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGAP15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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