Seroatlas · Human Serome Atlas

ARGFX

Arginine-fifty homeobox

Also known as: ARGFX_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NJG6
Gene: ARGFX
Ensembl: ENSG00000186103
Chromosome: 3
Canonical length: 315 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the ARGFX homeobox gene family. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>A6NJG6|ARGFX
     1  MRNRMAPENP QPDPFINRNY SNMKVIPPQD PASPSFTLLS KLECSGTVSA YCSLNLPGST
    61  DPPTSASRVA ATTAIRRRHK ERTSFTHQQY EELEALFSQT MFPDRNLQEK LALRLDLPES
   121  TVKVWFRNRR FKLKKQQQQQ SAKQRNQILP SKKNVPTSPR TSPSPYAFSP VISDFYSSLP
   181  SQPLDPSNWA WNSTFTESST SDFQMQDTQW ERLVASVPAL YSDAYDIFQI IELYNLPDEN
   241  EISSSSFHCL YQYLSPTKYQ VGGQGSSLSI FAGPAVGLSP AQTWPNMTSQ AFEAYSLTDS
   301  LEFQKTSNMV DLGFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARGFX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 1 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 1 nTPM
skin: 0.6 nTPM
retina: 0.5 nTPM
skeletal muscle: 0.4 nTPM
lymph node: 0.3 nTPM
pancreas: 0.3 nTPM

Single-cell type

cardiomyocytes: 49 nCPM
myonuclei: 10 nCPM
sertoli cells: 3.4 nCPM
thymic myoid cells: 2.7 nCPM
plasma cells: 2.2 nCPM
epididymal basal cells: 1.1 nCPM

Immune cell

neutrophil: 1.6 nTPM
basophil: 1.2 nTPM
naive B-cell: 0.5 nTPM
NK-cell: 0.5 nTPM
classical monocyte: 0.4 nTPM
memory B-cell: 0.4 nTPM

Brain region

cerebellum: 11 nTPM
white matter: 9.7 nTPM
cerebral cortex: 8.4 nTPM
pons: 7.9 nTPM
basal ganglia: 7.8 nTPM
choroid plexus: 7.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: 0.16
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARGFX as an antibody target. Whether an autoantibody or antibody against ARGFX could matter depends on whether native ARGFX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARGFX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARGFX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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