Seroatlas · Human Serome Atlas

AQP8

Aquaporin-8

Also known as: AQP8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94778
Gene: AQP8
Ensembl: ENSG00000103375
Chromosome: 16
Canonical length: 261 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>O94778|AQP8
     1  MSGEIAMCEP EFGNDKAREP SVGGRWRVSW YERFVQPCLV ELLGSALFIF IGCLSVIENG
    61  TDTGLLQPAL AHGLALGLVI ATLGNISGGH FNPAVSLAAM LIGGLNLVML LPYWVSQLLG
   121  GMLGAALAKA VSPEERFWNA SGAAFVTVQE QGQVAGALVA EIILTTLLAL AVCMGAINEK
   181  TKGPLAPFSI GFAVTVDILA GGPVSGGCMN PARAFGPAVV ANHWNFHWIY WLGPLLAGLL
   241  VGLLIRCFIG DGKTRLILKA R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AQP8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 1,207 nTPM

Expression across tissuesHPA

Tissue

pancreas: 1,207 nTPM
colon: 309 nTPM
rectum: 151 nTPM
cerebellum: 1.6 nTPM
basal ganglia: 1.3 nTPM
smooth muscle: 1.1 nTPM

Single-cell type

colonocytes: 1,687 nCPM
pancreatic acinar cells: 205 nCPM
tuft cells: 23 nCPM
mast cells: 19 nCPM
neuroendocrine cells: 8.2 nCPM
goblet cells: 5.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.1 nTPM
cerebellum: 1 nTPM
basal ganglia: 0.9 nTPM
hippocampal formation: 0.9 nTPM
amygdala: 0.8 nTPM
white matter: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ammonium transmembrane transport
B cell differentiation
cellular detoxification
cellular response to cAMP
hydrogen peroxide transmembrane transport
regulation of cholesterol biosynthetic process
transepithelial water transport
urea transport
water transport
ammonium import across plasma membrane
methylammonium transport

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AQP8 as an antibody target. Whether an autoantibody or antibody against AQP8 could matter depends on whether native AQP8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AQP8 is annotated at the cell surface, where native AQP8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AQP8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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