Seroatlas · Human Serome Atlas

AQP12B

Putative aquaporin-12B

Also known as: AQ12B_HUMAN, INSSA3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NM10
Gene: AQP12B
Ensembl: ENSG00000185176
Chromosome: 2
Canonical length: 295 aa
Protein class: Predicted membrane proteins
Quaternary structure: Homotetramer

OverviewNCBI Gene

Predicted to enable channel activity. Predicted to be involved in transmembrane transport and water transport. Predicted to be located in membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

295 residues, UniProt reviewed canonical sequence.

>A6NM10|AQP12B
     1  MAGLNVSLSF FFATFTLCEA ARRASKALLP VGAYEVFARE AMRTLVELGP WAGDFGPDLL
    61  LTLLFLLFLA HGVTLDGASA NPTVSLQEFL MAEESLPGTL LKLAAQGLGM QAACTLTRLC
   121  WAWELSDLHL LQSLMAQSCS SALRTSVPHG ALVEAACAFC FHLTLLHLRH SPPAYSGPAV
   181  ALLVTVTAYT AGPFTSAFFN PALAASVTFA CSGHTLLEYV QVYWLGPLTG MVLAVLLHQG
   241  RLPHLFQRNL FYGQKNKYRA PRGKPAPASG DTQTPAKGSS VREPGRSGVE GPHSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AQP12B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 201 nTPM

Expression across tissuesHPA

Tissue

pancreas: 201 nTPM
duodenum: 0.5 nTPM
colon: 0.4 nTPM
small intestine: 0.3 nTPM
cerebral cortex: 0.1 nTPM
salivary gland: 0.1 nTPM

Single-cell type

pancreatic acinar cells: 0.6 nCPM
enterocytes: 0.5 nCPM
colonocytes: 0.2 nCPM
enteric transient amplifying cells: 0.2 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.9 nTPM
pons: 1.6 nTPM
medulla oblongata: 1.3 nTPM
white matter: 0.9 nTPM
hypothalamus: 0.7 nTPM
amygdala: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: -1.47
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AQP12B as an antibody target. Whether an autoantibody or antibody against AQP12B could matter depends on whether native AQP12B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AQP12B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AQP12B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...