Seroatlas · Human Serome Atlas

AQP11

Aquaporin-11

Also known as: AQP11_HUMAN, AQPX1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NBQ7
Gene: AQP11
Ensembl: ENSG00000178301
Chromosome: 11
Canonical length: 271 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Vesicles,Plasma membrane
Quaternary structure: Homotetramer

OverviewNCBI Gene

Enables glycerol channel activity; hydrogen peroxide channel activity; and water channel activity. Involved in several processes, including glycerol transmembrane transport; hydrogen peroxide transmembrane transport; and intracellular water homeostasis. Located in cell surface; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>Q8NBQ7|AQP11
     1  MSPLLGLRSE LQDTCTSLGL MLSVVLLMGL ARVVARQQLH RPVAHAFVLE FLATFQLCCC
    61  THELQLLSEQ HPAHPTWTLT LVYFFSLVHG LTLVGTSSNP CGVMMQMMLG GMSPETGAVR
   121  LLAQLVSALC SRYCTSALWS LGLTQYHVSE RSFACKNPIR VDLLKAVITE AVCSFLFHSA
   181  LLHFQEVRTK LRIHLLAALI TFLVYAGGSL TGAVFNPALA LSLHFMCFDE AFPQFFIVYW
   241  LAPSLGILLM ILMFSFFLPW LHNNHTINKK E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AQP11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

duodenum: 27 nTPM
small intestine: 24 nTPM
liver: 15 nTPM
adrenal gland: 14 nTPM
testis: 7.7 nTPM
ovary: 7.2 nTPM

Single-cell type

late spermatids: 105 nCPM
late primary spermatocytes: 86 nCPM
enterocytes: 62 nCPM
hepatocytes: 50 nCPM
müller glia: 49 nCPM
early primary spermatocytes: 39 nCPM

Immune cell

NK-cell: 0.7 nTPM
naive CD4 T-cell: 0.6 nTPM
gdT-cell: 0.5 nTPM
naive B-cell: 0.5 nTPM
memory CD8 T-cell: 0.4 nTPM
MAIT T-cell: 0.3 nTPM

Brain region

cerebellum: 13 nTPM
pons: 11 nTPM
hypothalamus: 10 nTPM
medulla oblongata: 10 nTPM
basal ganglia: 10 nTPM
cerebral cortex: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: 0.62
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AQP11 as an antibody target. Whether an autoantibody or antibody against AQP11 could matter depends on whether native AQP11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AQP11 is annotated at the cell surface, where native AQP11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AQP11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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