Seroatlas · Human Serome Atlas

APRG1

APRG1 tumor suppressor candidate

Also known as: APRG1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IVJ8
Gene: APRG1
Canonical length: 170 aa

OverviewNCBI Gene

No narrative summary is available for APRG1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

170 residues, UniProt reviewed canonical sequence.

>Q8IVJ8|APRG1
     1  MKTMATRKRC KLSRTGPEFE NVIKRLLCAR TFHTRIGGDL THGIINRGRR ANAEQMGLQG
    61  SAQHFNIFPL DLWTQGKKTE VQKREGTDSI PAAGRSGTAN QPSIAPHRCL FSRGITALDG
   121  LKRGRGCNGA AHLVRGDAWK TKLGEPWVSI ALALAGPGAI LILELSWFLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APRG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.68

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APRG1 as an antibody target. Whether an autoantibody or antibody against APRG1 could matter depends on whether native APRG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APRG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label APRG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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