APOOL
MICOS complex subunit MIC27
Also known as: AAIR8193, CXorf33, FAM121A, Mic27, MIC27_HUMAN, MICOS27, UNQ8193
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UXV4
- Gene
- APOOL
- Ensembl
- ENSG00000155008
- Chromosome
- X
- Canonical length
- 268 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Mitochondria
OverviewNCBI Gene
This gene encodes a protein which contains an apolipoprotein O superfamily domain. This domain is found on proteins in circulating lipoprotein complexes. [provided by RefSeq, Sep 2011]
Canonical amino-acid sequenceUniProt
268 residues, UniProt reviewed canonical sequence.
>Q6UXV4|APOOL
1 MAAIRMGKLT TMPAGLIYAS VSVHAAKQEE SKKQLVKPEQ LPIYTAPPLQ SKYVEEQPGH
61 LQMGFASIRT ATGCYIGWCK GVYVFVKNGI MDTVQFGKDA YVYLKNPPRD FLPKMGVITV
121 SGLAGLVSAR KGSKFKKITY PLGLATLGAT VCYPVQSVII AKVTAKKVYA TSQQIFGAVK
181 SLWTKSSKEE SLPKPKEKTK LGSSSEIEVP AKTTHVLKHS VPLPTELSSE AKTKSESTSG
241 ATQFMPDPKL MDHGQSHPED IDMYSTRSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against APOOL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 2
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 17 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 17 nTPM
- tongue: 17 nTPM
- liver: 14 nTPM
- parathyroid gland: 11 nTPM
- heart muscle: 11 nTPM
- kidney: 10 nTPM
Single-cell type
- cardiomyocytes: 126 nCPM
- parietal cells: 115 nCPM
- megakaryocytes: 80 nCPM
- esophageal apical cells: 74 nCPM
- hepatocytes: 70 nCPM
- myonuclei: 62 nCPM
Immune cell
- intermediate monocyte: 2.8 nTPM
- plasmacytoid DC: 2.6 nTPM
- non-classical monocyte: 2.5 nTPM
- basophil: 2.3 nTPM
- memory B-cell: 2.1 nTPM
- myeloid DC: 2.1 nTPM
Brain region
- choroid plexus: 21 nTPM
- cerebral cortex: 20 nTPM
- pons: 19 nTPM
- thalamus: 19 nTPM
- medulla oblongata: 19 nTPM
- midbrain: 19 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 0.26
- DepMap mean gene effect
- -0.16
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads APOOL as an antibody target. Whether an autoantibody or antibody against APOOL could matter depends on whether native APOOL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
APOOL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label APOOL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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