Seroatlas · Human Serome Atlas

APOLD1

Apolipoprotein L domain-containing protein 1

Also known as: APLD1_HUMAN, DKFZP434F0318, FLJ25138

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LR9
Gene: APOLD1
Ensembl: ENSG00000178878
Chromosome: 12
Canonical length: 279 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

APOLD1 is an endothelial cell early response protein that may play a role in regulation of endothelial cell signaling and vascular function (Regard et al., 2004 [PubMed 15102925]).[supplied by OMIM, Dec 2008]

Canonical amino-acid sequenceUniProt

279 residues, UniProt reviewed canonical sequence.

>Q96LR9|APOLD1
     1  MFRAPCHRLR ARGTRKARAG AWRGCTFPCL GKGMERPAAR EPHGPDALRR FQGLLLDRRG
    61  RLHGQVLRLR EVARRLERLR RRSLVANVAG SSLSATGALA AIVGLSLSPV TLGTSLLVSA
   121  VGLGVATAGG AVTITSDLSL IFCNSRELRR VQEIAATCQD QMREILSCLE FFCRWQGCGD
   181  RQLLQCGRNA SIALYNSVYF IVFFGSRGFL IPRRAEGDTK VSQAVLKAKI QKLAESLESC
   241  TGALDELSEQ LESRVQLCTK SSRGHDLKIS ADQRAGLFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APOLD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 117 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 117 nTPM
breast: 90 nTPM
placenta: 81 nTPM
thyroid gland: 61 nTPM
heart muscle: 54 nTPM
blood vessel: 51 nTPM

Single-cell type

vascular smooth muscle cells: 368 nCPM
vascular endothelial cells: 309 nCPM
pericytes: 301 nCPM
lymphatic endothelial cells: 254 nCPM
müller glia: 241 nCPM
retinal pigment epithelial cells: 239 nCPM

Immune cell

basophil: 2.2 nTPM
neutrophil: 1.6 nTPM
T-reg: 1.1 nTPM
memory B-cell: 1 nTPM
naive B-cell: 0.8 nTPM
memory CD4 T-cell: 0.7 nTPM

Brain region

thalamus: 67 nTPM
pons: 53 nTPM
medulla oblongata: 49 nTPM
amygdala: 47 nTPM
midbrain: 44 nTPM
cerebral cortex: 41 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about APOLD1.

Disease | AllUniProt

Conditions APOLD1 is implicated in, by any mechanism.

Bleeding disorder, vascular-type (BDVAS) MIM:620715

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: 0.45
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

angiogenesis
lipid transport
lipoprotein metabolic process
regulation of endothelial cell differentiation
regulation of membrane permeability
autophagosome-dependent secretion

Molecular functions

lipid binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APOLD1 as an antibody target. Whether an autoantibody or antibody against APOLD1 could matter depends on whether native APOLD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APOLD1 is annotated at the cell surface, where native APOLD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label APOLD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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