Seroatlas · Human Serome Atlas

APOL6

Apolipoprotein L6

Also known as: APOL-VI, APOL6_HUMAN, APOLVI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWW8
Gene: APOL6
Ensembl: ENSG00000221963
Chromosome: 22
Canonical length: 343 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

343 residues, UniProt reviewed canonical sequence.

>Q9BWW8|APOL6
     1  MDNQAERESE AGVGLQRDED DAPLCEDVEL QDGDLSPEEK IFLREFPRLK EDLKGNIDKL
    61  RALADDIDKT HKKFTKANMV ATSTAVISGV MSLLGLALAP ATGGGSLLLS TAGQGLATAA
   121  GVTSIVSGTL ERSKNKEAQA RAEDILPTYD QEDREDEEEK ADYVTAAGKI IYNLRNTLKY
   181  AKKNVRAFWK LRANPRLANA TKRLLTTGQV SSRSRVQVQK AFAGTTLAMT KNARVLGGVM
   241  SAFSLGYDLA TLSKEWKHLK EGARTKFAEE LRAKALELER KLTELTQLYK SLQQKVRSRA
   301  RGVGKDLTGT CETEAYWKEL REHVWMWLWL CVCLCVCVYV QFT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APOL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

liver: 44 nTPM
adipose tissue: 22 nTPM
small intestine: 19 nTPM
duodenum: 18 nTPM
spleen: 17 nTPM
bone marrow: 15 nTPM

Single-cell type

hepatocytes: 155 nCPM
adipocytes: 142 nCPM
nk-cells: 121 nCPM
alveolar cells type 1: 104 nCPM
enterocytes: 103 nCPM
foveolar cells: 94 nCPM

Immune cell

non-classical monocyte: 8.6 nTPM
intermediate monocyte: 7.6 nTPM
basophil: 7.5 nTPM
neutrophil: 7.5 nTPM
gdT-cell: 7.3 nTPM
MAIT T-cell: 6.1 nTPM

Brain region

medulla oblongata: 24 nTPM
spinal cord: 19 nTPM
pons: 17 nTPM
white matter: 16 nTPM
thalamus: 16 nTPM
midbrain: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0.1
gnomAD missense Z: 0
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

lipid binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APOL6 as an antibody target. Whether an autoantibody or antibody against APOL6 could matter depends on whether native APOL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APOL6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label APOL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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