Seroatlas · Human Serome Atlas

APOL5

Apolipoprotein L5

Also known as: APOL5_HUMAN, APOLV

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWW9
Gene: APOL5
Ensembl: ENSG00000128313
Chromosome: 22
Canonical length: 433 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

433 residues, UniProt reviewed canonical sequence.

>Q9BWW9|APOL5
     1  MPCGKQGNLQ VPGSKVLPGL GEGCKEMWLR KVIYGGEVWG KSPEPEFPSL VNLCQSWKIN
    61  NLMSTVHSDE AGMLSYFLFE ELMRCDKDSM PDGNLSEEEK LFLSYFPLHK FELEQNIKEL
   121  NTLADQVDTT HELLTKTSLV ASSSGAVSGV MNILGLALAP VTAGGSLMLS ATGTGLGAAA
   181  AITNIVTNVL ENRSNSAARD KASRLGPLTT SHEAFGGINW SEIEAAGFCV NKCVKAIQGI
   241  KDLHAYQMAK SNSGFMAMVK NFVAKRHIPF WTARGVQRAF EGTTLAMTNG AWVMGAAGAG
   301  FLLMKDMSSF LQSWKHLEDG ARTETAEELR ALAKKLEQEL DRLTQHHRHL PQKASQTCSS
   361  SRGRAVRGSR VVKPEGSRSP LPWPVVEHQP RLGPGVALRT PKRTVSAPRM LGHQPAPPAP
   421  ARKGRQAPGR HRQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APOL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 1.9 nTPM

Expression across tissuesHPA

Tissue

tongue: 1.9 nTPM
skeletal muscle: 1.3 nTPM
testis: 0.6 nTPM
liver: 0.4 nTPM
heart muscle: 0.2 nTPM
adipose tissue: 0.1 nTPM

Single-cell type

late primary spermatocytes: 0.7 nCPM
renal connecting tubule cells: 0.5 nCPM
early spermatids: 0.3 nCPM
podocytes: 0.3 nCPM
proximal tubule cells: 0.3 nCPM
myonuclei: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.4 nTPM
hippocampal formation: 0.3 nTPM
amygdala: 0.2 nTPM
cerebellum: 0.2 nTPM
white matter: 0.2 nTPM
basal ganglia: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
gnomAD missense Z: 0.37
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APOL5 as an antibody target. Whether an autoantibody or antibody against APOL5 could matter depends on whether native APOL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APOL5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label APOL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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