Seroatlas · Human Serome Atlas

APOL4

Apolipoprotein L4

Also known as: APOL4_HUMAN, APOLIV

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BPW4
Gene: APOL4
Ensembl: ENSG00000100336
Chromosome: 22
Canonical length: 351 aa
Protein class: Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the apolipoprotein L family. The encoded protein may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2020]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>Q9BPW4|APOL4
     1  MEGAALLKIF VVCIWVQQNH PGWTVAGQFQ EKKRFTEEVI EYFQKKVSPV HLKILLTSDE
    61  AWKRFVRVAE LPREEADALY EALKNLTPYV AIEDKDMQQK EQQFREWFLK EFPQIRWKIQ
   121  ESIERLRVIA NEIEKVHRGC VIANVVSGST GILSVIGVML APFTAGLSLS ITAAGVGLGI
   181  ASATAGIASS IVENTYTRSA ELTASRLTAT STDQLEALRD ILRDITPNVL SFALDFDEAT
   241  KMIANDVHTL RRSKATVGRP LIAWRYVPIN VVETLRTRGA PTRIVRKVAR NLGKATSGVL
   301  VVLDVVNLVQ DSLDLHKGAK SESAESLRQW AQELEENLNE LTHIHQSLKA G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APOL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

lung: 14 nTPM
prostate: 14 nTPM
urinary bladder: 11 nTPM
gallbladder: 6.6 nTPM
adipose tissue: 6.3 nTPM
heart muscle: 6 nTPM

Single-cell type

endometrial luminal cells: 104 nCPM
fallopian tube ciliated cells: 48 nCPM
prostatic glandular cells: 30 nCPM
endometrial glandular cells: 27 nCPM
somatotrophs: 22 nCPM
prostatic hillock cells: 19 nCPM

Immune cell

classical monocyte: 2.1 nTPM
myeloid DC: 1.7 nTPM
intermediate monocyte: 1.4 nTPM
neutrophil: 1.4 nTPM
basophil: 1.2 nTPM
total PBMC: 0.8 nTPM

Brain region

cerebellum: 23 nTPM
hypothalamus: 22 nTPM
midbrain: 21 nTPM
cerebral cortex: 21 nTPM
medulla oblongata: 21 nTPM
white matter: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about APOL4.

Disease | ImmuneIEDB

Conditions an epitope on APOL4 was assayed in.

type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0
gnomAD missense Z: -0.02

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

lipid binding

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APOL4 as an antibody target. Whether an autoantibody or antibody against APOL4 could matter depends on whether native APOL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APOL4 is annotated as secreted, so native APOL4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label APOL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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